Novel histone deacetylase inhibitors:: N-hydroxycarboxamides possessing a terminal bicyclic aryl group

被引：38

作者：

Uesato, S ^{[1
]}

Kitagawa, M

Nagaoka, Y

Maeda, T

Kuwajima, H

Yamori, T

机构：

[1] Kansai Univ, Fac Engn, Dept Biotechnol, Suita, Osaka 5648680, Japan

[2] Kinki Univ, Fac Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan

[3] Japanese Fdn Canc Res, Div Expt Chemotherapy, Ctr Canc Chemotherapy, Toshima Ku, Tokyo 1708455, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(02)00175-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with the 1,4-phenylene group yielded the promising HDAC inhibitors which possess a terminal bicyclic aryl amide. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1347 / 1349

页数：3

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