Low expression of Foxo3a is Associated with Poor Prognosis in Ovarian Cancer Patients

被引：76

作者：

Fei, Min ^{[2
]}

Zhao, Yueming ^{[3
]}

Wang, Yuchan ^{[3
]}

Lu, Mudan ^{[3
]}

Cheng, Chun ^{[3
]}

Huang, Xiaodong ^{[3
]}

Zhang, Dongmei ^{[3
]}

Lu, Jianxin ^{[3
]}

He, Song ^{[3
]}

Shen, Aiguo ^{[1
]}

机构：

[1] Nantong Univ, Jiangsu Prov Key Lab Neuroregenerat, Nantong 226001, Peoples R China

[2] Soochow Univ, Inst Med Biotechnol, Suzhou, Peoples R China

[3] Nantong Univ, Coll Med, Affiliated Canc Hosp, Dept Pthol, Nantong, Peoples R China

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 01期

关键词：

Ovarian cancer; Foxo3a; p27kip1; FORKHEAD TRANSCRIPTION FACTOR; DEPENDENT KINASE INHIBITOR; ONCOLOGY-GROUP EXPERIENCE; CELL-CYCLE; FACTOR FKHR; BREAST-CANCER; P27(KIP1); PROTEIN; CARCINOMA; SURVIVAL;

D O I：

10.1080/07357900802146204

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate whether Foxo3a expression is correlated with p27kip1 protein levels as well as how it might be clinically relevant, we evaluated the expression of Foxo3a in several ovarian tumors. Immunohistochemical analysis was performed in 63 cases of ovarian tumors. Ten cases were evaluated by Western blot analysis. There was a correlation observed between Foxo3a over-expression and clinic pathological parameters (p = 0.032). Kaplan-Meier survival analysis showed that Foxo3a low expression was significantly associated with poor prognosis of patients. It may be a useful prognostic marker and target in ovarian cancer.

引用

页码：52 / 59

页数：8

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