Gingipain adhesin domains mediate Porphyromonas gingivalis adherence to epithelial cells

被引：53

作者：

Chen, T ^{[1
]}

Duncan, MJ ^{[1
]}

机构：

[1] Forsyth Inst, Dept Mol Genet, Boston, MA 02115 USA

来源：

MICROBIAL PATHOGENESIS | 2004年 / 36卷 / 04期

关键词：

Porphyromonas gingivalis; gingipain; adherence; epithelia;

D O I：

10.1016/j.micpath.2003.12.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Porphyromonas gingivalis, a Gram-negative oral anaerobe, interacts with epithelium lining the gingival sulcus. Continuing our studies on the role of gingipain cysteine proteinases in P. gingivalis adherence to epithelial cells, we showed that antibody raised to the recombinant adhesin domain of arg-gingipain A blocked bacterial attachment, providing new additional evidence that P. gingivalis adherence to epithelial cells is mediated by gingipain adhesin peptides. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：205 / 209

页数：5

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