Defense responses of dentin/pulp complex to experimentally induced caries in rat molars: An immunohistochemical study on kinetics of pulpal Ia antigen-expressing cells and macrophages.

被引:38
作者
Kamal, AMM [1 ]
Okiji, T [1 ]
Kawashima, N [1 ]
Suda, H [1 ]
机构
[1] TOKYO MED & DENT UNIV,FAC DENT,DEPT ENDODONT,BUNKYO KU,TOKYO 113,JAPAN
关键词
D O I
10.1016/S0099-2399(97)80257-9
中图分类号
R78 [口腔科学];
学科分类号
1003 [口腔医学];
摘要
Experimental caries was induced in rats that were innoculated orally with Streptococcus mutants and maintained on a cariogenic diet, During the caries process, kinetics of the pulpal Ia antigen-expressing cells and macrophages was monitored immunohistochemically and was correlated with caries depth and the status of reparative dentin formation. Initial pulpal response was characterized by a localized accumulation of Ia antigen-expressing cells beneath the dentinal tubules communicating with the superficial caries. This was followed by a caries-depth related increase of Ia antigen-expressing cells and macrophages in the coronal pulp, The accumulation of these cells under the dentin was most apparent when the caries had progressed into the reparative dentin, These findings suggest that the response of Ia antigen-expressing cells to carious irritants triggers the defense reactions of the pulp. The intensity of the defense reactions may be correlated with the permeability of carious dentin.
引用
收藏
页码:115 / 120
页数:6
相关论文
共 20 条
[1]
PATHOGENIC MECHANISMS IN PULPAL DISEASE [J].
BERGENHOLTZ, G .
JOURNAL OF ENDODONTICS, 1990, 16 (02) :98-101
[2]
CLASS-II ANTIGEN EXPRESSING CELLS IN EXPERIMENTALLY INDUCED PULPITIS [J].
BERGENHOLTZ, G ;
NAGAOKA, S ;
JONTELL, M .
INTERNATIONAL ENDODONTIC JOURNAL, 1991, 24 (01) :8-14
[3]
DENTAL-CARIES INDUCTION IN EXPERIMENTAL-ANIMALS BY CLINICAL STRAINS OF STREPTOCOCCUS-MUTANS ISOLATED FROM JAPANESE CHILDREN [J].
HAMADA, S ;
OOSHIMA, T ;
TORII, M ;
IMANISHI, H ;
MASUDA, N ;
SOBUE, S ;
KOTANI, S .
MICROBIOLOGY AND IMMUNOLOGY, 1978, 22 (06) :301-314
[4]
Heyeraas K J, 1992, Proc Finn Dent Soc, V88 Suppl 1, P393
[5]
IMMUNOHISTOCHEMICAL STUDY ON THE IMMUNOCOMPETENT CELLS OF THE PULP IN HUMAN NONCARIOUS AND CARIOUS TEETH [J].
IZUMI, T ;
KOBAYASHI, I ;
OKAMURA, K ;
SAKAI, H .
ARCHIVES OF ORAL BIOLOGY, 1995, 40 (07) :609-614
[6]
IMMUNOCOMPETENT CELLS IN THE NORMAL DENTAL-PULP [J].
JONTELL, M ;
GUNRAJ, MN ;
BERGENHOLTZ, G .
JOURNAL OF DENTAL RESEARCH, 1987, 66 (06) :1149-1153
[7]
DENDRITIC CELLS AND MACROPHAGES EXPRESSING CLASS-II ANTIGENS IN THE NORMAL RAT INCISOR PULP [J].
JONTELL, M ;
BERGENHOLTZ, G ;
SCHEYNIUS, A ;
AMBROSE, W .
JOURNAL OF DENTAL RESEARCH, 1988, 67 (10) :1263-1266
[8]
JONTELL M, 1992, P FINN DENT SOC S1, V88, P345
[9]
KAMAL AMM, 1995, P INT C DENT PULP CO
[10]
KIM S, 1994, PATHWAYS PULP, P414