Excess electron transport through DNA: A single electron repairs more than one UV-induced lesion

被引：71

作者：

Giese, B

Carl, B

Carl, T

Carell, T

Behrens, C

Hennecke, U

Schiemann, O

Feresin, E

机构：

[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

[2] Univ Marburg, Dept Chem, D-35032 Marburg, Germany

[3] Univ Frankfurt, Inst Phys & Theoret Chem, D-60439 Frankfurt, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 14期

关键词：

DNA damage; electron transfer; ESR spectroscopy; nucleotides; radical ions;

D O I：

10.1002/anie.200353264

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Site-selective injection of a single electron into thymine (yellow) through the modified nucleoside 1 (1→2) was used to examine the dependence of excess electron transfer in DNA on distance. The DNA was cleaved upon arrival of the electron at a thymine dimer (red). This assay showed that one electron can repair more than one UV-induced lesion in DNA 3.

引用

页码：1848 / 1851

页数：4

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