Staging of neurofibrillary pathology in Alzheimer's disease:: A study of the BrainNet Europe consortium

被引：358

作者：

Alafuzoff, Irina ^{[1
]}

Arzberger, Thomas ^{[2
]}

Al-Sarraj, Safa ^{[3
,4
]}

Bodi, Istvan ^{[3
,4
]}

Bogdanovic, Nenad ^{[5
]}

Braak, Heiko ^{[6
]}

Bugiani, Orso ^{[7
]}

Del-Tredici, Kelly ^{[6
]}

Ferrer, Isidro ^{[8
]}

Gelpi, Ellen ^{[9
]}

Giaccone, Giorgio ^{[7
]}

Graeber, Manuel B. ^{[10
]}

Ince, Paul ^{[11
]}

Kamphorst, Wouter ^{[12
]}

King, Andrew ^{[3
,4
]}

Korkolopoulou, Penelope ^{[13
]}

Kovacs, Gabor G. ^{[14
]}

Larionov, Sergey ^{[15
]}

Meyronet, David ^{[16
]}

Monoranu, Camelia ^{[17
]}

Parchi, Piero ^{[18
]}

Patsouris, Efstratios ^{[13
]}

Roggendorf, Wolfgang ^{[17
]}

Seilhean, Danielle ^{[19
,20
]}

Tagliavini, Fabrizio ^{[7
]}

Stadelmann, Christine ^{[21
]}

Streichenberger, Nathalie ^{[16
]}

Thal, Dietmar R. ^{[15
,22
]}

Wharton, Stephen B. ^{[11
]}

Kretzschmar, Hans ^{[2
]}

机构：

[1] Univ Kuopio, Dept Neurosci & Neurol, FIN-70211 Kuopio, Finland

[2] Univ Munich, Ctr Neuropathol & Prion Res, Munich, Germany

[3] Kings Coll Hosp London, Dept Clin Neuropathol, London, England

[4] Kings Coll London, Inst Psychiat, London, England

[5] Karolinska Inst, Dept Geriatr, Huddinge, Sweden

[6] Inst Clin Neuroanat, Inst Neuropathol, Frankfurt, Germany

[7] Fdn IRCCS, Ist Neurol Carlo Besta, Milan, Italy

[8] Univ Barcelona, Inst Neuropatol, Barcelona, Spain

[9] Med Univ Vienna, Inst Neurol, Vienna, Austria

[10] Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England

[11] Univ Sheffield, Sch Med, Acad Nit Pathol, Sheffield, S Yorkshire, England

[12] Netherlands Brain Bank, Amsterdam, Netherlands

[13] Natl & Capodistrian Univ Athens, Dept Pathol, Athens, Greece

[14] Natl Inst Psychiat & Neurol, OPNI, Budapest, Hungary

[15] Univ Bonn, Inst Neuropathol, D-5300 Bonn, Germany

[16] Univ Lyon 1, Fac Med Laennec, Hosp Civils Lyon, Ctr Pathol & Neuropathol Est, F-69365 Lyon, France

[17] Univ Wurzburg, Inst Pathol, Abt Neuropathol, D-8700 Wurzburg, Germany

[18] Univ Bologna, Dipartimento Sci Neurol, Bologna, Italy

[19] Univ Paris 06, Lab Neuropathol Raymond Escourolle, Paris, France

[20] INSERM, Paris, France

[21] Univ Klinikum, Gottingen, Germany

[22] Univ Ulm, Inst Pathol, Neuropathol Lab, Ulm, Germany

来源：

BRAIN PATHOLOGY | 2008年 / 18卷 / 04期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; immunohistochemistry; neurofibrillary pathology; neuropathological diagnosis; BrainNet Europe consortium;

D O I：

10.1111/j.1750-3639.2008.00147.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in the future. Consequently, in order to reach a diagnosis of Alzheimer's disease (AD), the presence of hyperphosphorylated tau (HP-tau) and beta-amyloid protein in brain tissue must be unequivocal. In addition, the stepwise progression of pathology needs to be assessed. This paper deals exclusively with the regional assessment of AD-related HP-tau pathology. The objective was to provide straightforward instructions to aid in the assessment of AD-related immunohistochemically (IHC) detected HP-tau pathology and to test the concordance of assessments made by 25 independent evaluators. The assessment of progression in 7-mu m-thick sections was based on assessment of IHC labeled HP-tau immunoreactive neuropil threads (NTs). Our results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures (stage V-VI absolute agreement 91%), whereas when only mild subtle lesions were present the agreement was poorer (I-II absolute agreement 50%). Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.

引用

页码：484 / 496

页数：13

共 22 条

[1] Global democratic consensus on neuropathological disease criteria [J].

Achim, C ;

Auer, R ;

Bergeron, C ;

Cardozo, A ;

Deprez, M ;

de Vos, R ;

Duyckaerts, C ;

Egensperger, R ;

Esiri, M ;

Frosch, MP ;

Giannini, C ;

Goebel, HH ;

Graeber, MB ;

Graham, DI ;

Gray, F ;

Haltia, M ;

Hashizuma, Y ;

Ikeda, K ;

Ironside, JW ;

Kreutzberg, GW ;

Lantos, P ;

Lowee, J ;

Ludwin, S ;

Matsumoto, Y ;

Olsson, Y ;

Sasaki, A ;

Scheithauer, BW ;

Takahashi, H ;

Tolnay, M ;

Trojanowski, JQ ;

Troost, D ;

Webster, HD .

LANCET NEUROLOGY, 2002, 1 (06) :340-340

[2] Interlaboratory comparison of assessments of Alzheimer disease-related lesions:: a study of the BrainNet Europe consortium [J].

Alafuzoff, Irina ;

Pikkarainen, Maria ;

Al-Sarraj, Safa ;

Arzberger, Thomas ;

Bell, Jeanne ;

Bodi, Istvan ;

Bogdanovic, Nenad ;

Budka, Herbert ;

Bugiani, Orso ;

Ferrer, Isidro ;

Gelpi, Ellen ;

Giaccone, Giorgio ;

Graeber, Manuel B. ;

Hauw, Jean-Jacques ;

Kamphorst, Wouter ;

King, Andrew ;

Kopp, Nicolas ;

Korkolopoulou, Penelope ;

Kovacs, Gdbor G. ;

Meyronet, David ;

Parchi, Piero ;

Patsouris, Efstratios ;

Preusser, Matthias ;

Ravid, Rivka ;

Roggendorf, Wolfgang ;

Seilhean, Danielle ;

Streichenberger, Nathalie ;

Thal, Dietmar R. ;

Kretzschmar, Hans .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2006, 65 (08) :740-757

[3] Argyrophilic grain disease: frequency of occurrence in different age categories and neuropathological diagnostic criteria [J].

Braak, H ;

Braak, E .

JOURNAL OF NEURAL TRANSMISSION, 1998, 105 (8-9) :801-819

[4] Staging of brain pathology related to sporadic Parkinson's disease [J].

Braak, H ;

Del Tredici, K ;

Rüb, U ;

de Vos, RAI ;

Steur, ENHJ ;

Braak, E .

NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211

[5] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[6] Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry [J].

Braak, Heiko ;

Alafuzoff, Irina ;

Arzberger, Thomas ;

Kretzschmar, Hans ;

Del Tredici, Kelly .

ACTA NEUROPATHOLOGICA, 2006, 112 (04) :389-404

[7] RATING OF THE LESIONS IN SENILE DEMENTIA OF THE ALZHEIMER TYPE - CONCORDANCE BETWEEN LABORATORIES - A EUROPEAN MULTICENTER STUDY UNDER THE AUSPICES OF EURAGE [J].

DUYCKAERTS, C ;

DELAERE, P ;

HAUW, JJ ;

ABBAMONDIPINTO, AL ;

SORBI, S ;

ALLEN, I ;

BRION, JP ;

FLAMENTDURAND, J ;

DUCHEN, L ;

KAUSS, J ;

SCHLOTE, W ;

LOWE, J ;

PROBST, A ;

RAVID, R ;

SWAAB, DF ;

RENKAWEK, K ;

TOMLINSON, B .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1990, 97 (2-3) :295-323

[8]

GUSTAFFSON L, 1997, CEREBRAL VASCULAR DI, P5

[9] DIAGNOSIS OF ALZHEIMERS-DISEASE [J].

KHACHATURIAN, ZS .

ARCHIVES OF NEUROLOGY, 1985, 42 (11) :1097-1104

[10] Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees [J].

Klunk, William E. ;

Price, Julie C. ;

Mathis, Chester A. ;

Tsopelas, Nicholas D. ;

Lopresti, Brian J. ;

Ziolko, Scott K. ;

Bi, Wenzhu ;

Hoge, Jessica A. ;

Cohen, Ann D. ;

Ikonomovic, Milos D. ;

Saxton, Judith A. ;

Snitz, Beth E. ;

Pollen, Daniel A. ;

Moonis, Majaz ;

Lippa, Carol F. ;

Swearer, Joan M. ;

Johnson, Keith A. ;

Rentz, Dorene M. ;

Fischman, Alan J. ;

Aizenstein, Howard J. ;

DeKosky, Steven T. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (23) :6174-6184

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