Mechanism of Magnetic Relaxation Switching Sensing

被引：109

作者：

Min, Changwook ^{[1
]}

Shao, Huilin ^{[1
]}

Liong, Monty ^{[1
]}

Yoon, Tae-Jong ^{[1
]}

Weissleder, Ralph ^{[1
,2
]}

Lee, Hakho ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

ACS NANO | 2012年 / 6卷 / 08期

关键词：

magnetic relaxation switching; magnetic nanoparticles; NMR; biosensors; DIFFUSION-LIMITED AGGREGATION; MRI CONTRAST AGENTS; NANOPARTICLES; PROTEINS; SPHERES;

D O I：

10.1021/nn301615b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnetic relaxation switching (MRSw) assays that employ target-induced aggregation (or disaggregation) of magnetic nanoparticles (MNPs) can be used to detect a wide range of biomolecules. The precise working mechanisms, however, remain poorly understood, often leading to confounding interpretation. We herein present a systematic and comprehensive characterization of MRSw sensing. By using different types of MNPs with varying physical properties, we analyzed the nature and transverse relaxation modes for MRSw detection. The study found that clustered MNPs are universally in a diffusion-limited fractal state (dimension of similar to 2.4). Importantly, a new model for transverse relaxation was constructed that accurately recapitulates observed MRSw phenomena and predicts the MRSw detection sensitivities and dynamic ranges.

引用

页码：6821 / 6828

页数：8

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