Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic options

被引：17

作者：

Audrito, Valentina ^{[1
,2
]}

Vaisitti, Tiziana ^{[1
,2
]}

Serra, Sara ^{[1
,2
]}

Bologna, Cinzia ^{[1
,2
]}

Brusa, Davide ^{[2
]}

Malavasi, Fabio ^{[1
]}

Deaglio, Silvia ^{[1
,2
]}

机构：

[1] Univ Turin, Sch Med, Dept Med Sci, I-10126 Turin, Italy

[2] Human Genet Fdn HuGeF, I-10126 Turin, Italy

来源：

CANCER LETTERS | 2013年 / 328卷 / 01期

关键词：

CLL; Microenvironment; Survival signals; Targeted therapies; CLL B-CELLS; LYMPH-NODE MICROENVIRONMENT; ENDOTHELIAL GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; IN-VITRO; T-CELLS; RECEPTOR COMPLEX; PI3K/NF-KAPPA-B PATHWAY; ALPHA-4-BETA-1; INTEGRIN; TUMOR MICROENVIRONMENT;

D O I：

10.1016/j.canlet.2012.08.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Chronic lymphocytic leukemia (CLL) cells display features consistent with a defect in apoptosis and exhibit prolonged survival in vivo. Survival of these malignant cells is influenced by interactions with non-leukemic cells located in permissive niches in lymphoid organs. Leukemic cells subvert the normal architecture of the lymphoid organs, recruiting stromal cells, dendritic cells and T lymphocytes, all reported as playing active roles in the survival and proliferation of CLL. The same survival-promoting environment also rescues/protects leukemic cells from cytotoxic therapies, giving way to disease relapse. This review summarizes and discusses current knowledge about the intricate network of soluble and cell-bound signals regulating the life and death of CLL cells in different districts. At the same time, it seeks to hone in on which discrete molecular elements are best suited as targets for treating this still incurable disease. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：27 / 35

页数：9

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