Immobilization of gold nanoparticles on solid supports utilizing DNA hybridization

被引:16
作者
Peschel, S
Ceyhan, B
Niemeyer, CM
Gao, S
Chi, L
Simon, U
机构
[1] Rhein Westfal TH Aachen, Inst Anorgan Chem, D-52056 Aachen, Germany
[2] Univ Bremen, D-28359 Bremen, Germany
[3] Univ Munster, Inst Phys, D-48149 Munster, Germany
来源
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2002年 / 19卷 / 1-2期
关键词
gold nanoparticles; nucleic acids; surface nanostructures; self-assembly;
D O I
10.1016/S0928-4931(01)00429-5
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Self-organization of colloidal metal nanoparticles into micro- and nanostructured assemblies is currently of tremendous interest promising to find new size- and structure-dependent physical properties. Owing to its unique recognition capabilities and physicochemical stability, DNA can be used as a molecular linker for gold nanoparticles and is a promising construction material for their precise spatial positioning. Due to the enormous specificity of nucleic acid hybridization, the site-specific immobilization of DNA-functionalized gold colloids (1-40 nm) to solid supports, previously functionalized with a complementary DNA array, allows the fabrication of novel nanostructured surface architectures. Scanning force microscopy (SFM), used to characterize the intermediate steps of the DNA-directed immobilization (DDI) on a gold substrate, provides initial insight into the specificity and efficiency of this technique. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:47 / 50
页数:4
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