Tumor cell recognition by γδ T lymphocytes T-cell receptor vs. NK-cell receptors

被引：91

作者：

Correia, Daniel V. ^{[1
]}

Lopes, Antonio ^{[1
,2
]}

Silva-Santos, Bruno ^{[1
,3
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal

[2] Univ Glasgow, Ctr Virus Res, MRC, Glasgow, Lanark, Scotland

[3] Inst Gulbenkian Ciencias, Oeiras, Portugal

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 01期

基金：

欧洲研究理事会;

关键词：

gamma delta T cell; NK cell; NKG2D; NK receptor; T-cell receptor; CLASS-I; STRESS-SURVEILLANCE; NONPEPTIDE ANTIGENS; NKG2D; CYTOTOXICITY; ACTIVATION; LYSIS; MICA; IMMUNOSURVEILLANCE; IMMUNOTHERAPY;

D O I：

10.4161/onci.22892

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The dissection of the molecular mechanisms underlying tumor-cell recognition by γδ T-cells is crucial to improve their performance in cancer immunotherapy. Here, we discuss the controversy around the relative contributions of the γδ T-cell receptor (TCR) and natural killer receptors (NKRs) to tumor-cell targeting by γδ T cells. © 2013 Landes Bioscience.

引用

页数：5

共 36 条

[1]

Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA [J].

Bauer, Stefan ;

Groh, Veronika ;

Wu, Jun ;

Steinle, Alexander ;

Phillips, Joseph H. ;

Lanier, Lewis L. ;

Spies, Thomas .

JOURNAL OF IMMUNOLOGY, 2018, 200 (07) :2231-2233

[2]

γδ T cell effector functions: a blend of innate programming and acquired plasticity [J].

Bonneville, Marc ;

O'Brien, Rebecca L. ;

Born, Willi K. .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (07) :467-478

[3]

BUKOWSKI JF, 1995, J IMMUNOL, V154, P998

[4]

HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells [J].

Carbone, E ;

Neri, P ;

Mesuraca, M ;

Fulciniti, MT ;

Otsuki, T ;

Pende, D ;

Groh, V ;

Spies, T ;

Pollio, G ;

Cosman, D ;

Catalano, L ;

Tassone, P ;

Rotoli, B ;

Venuta, S .

BLOOD, 2005, 105 (01) :251-258

[5]

Major histocompatibility complex class I molecules modulate activation threshold and early signaling of T cell antigen receptor gamma/delta stimulated by nonpeptidic ligands [J].

Carena, I ;

Shamshiev, A ;

Donda, A ;

Colonna, M ;

DeLibero, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (10) :1769-1774

[6]

Differentiation of human peripheral blood Vδ1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells [J].

Correia, Daniel V. ;

Fogli, Manuela ;

Hudspeth, Kelly ;

da Silva, Maria Gomes ;

Mavilio, Domenico ;

Silva-Santos, Bruno .

BLOOD, 2011, 118 (04) :992-1001

[7]

MICA engagement by human Vγ2Vδ2 T cells enhances their antigen-dependent effector function [J].

Das, H ;

Groh, V ;

Kuijl, C ;

Sugita, M ;

Morita, CT ;

Spies, T ;

Bukowski, JF .

IMMUNITY, 2001, 15 (01) :83-93

[8]

GAMMA-DELTA-T-CELL CLONES AND NATURAL-KILLER-CELL CLONES MEDIATE DISTINCT PATTERNS OF NONMAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED CYTOLYSIS [J].

FISCH, P ;

MALKOVSKY, M ;

BRAAKMAN, E ;

STURM, E ;

BOLHUIS, RLH ;

PRIEVE, A ;

SOSMAN, JA ;

LAM, VA ;

SONDEL, PM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (05) :1567-1579

[9]

Regulation of cutaneous malignancy by γδ T cells [J].

Girardi, M ;

Oppenheim, DE ;

Steele, CR ;

Lewis, JM ;

Glusac, E ;

Filler, R ;

Hobby, P ;

Sutton, B ;

Tigelaar, RE ;

Hayday, AC .

SCIENCE, 2001, 294 (5542) :605-609

[10]

Human T cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells [J].

Gober, HJ ;

Kistowska, M ;

Angman, L ;

Jenö, P ;

Mori, L ;

De Libero, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (02) :163-168

← 1 2 3 4 →