Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer

被引：99

作者：

Pere, Helene ^{[1
,2
]}

Tanchot, Corinne ^{[1
]}

Bayry, Jagadeesh ^{[3
]}

Terme, Magali ^{[1
]}

Taieb, Julien ^{[1
]}

Badoual, Cecile ^{[1
,4
]}

Adotevi, Olivier ^{[5
]}

Merillon, Nathalie ^{[1
]}

Marcheteau, Elie ^{[1
]}

Quillien, Veronique ^{[6
]}

Banissi, Claire ^{[7
]}

Carpentier, Alain ^{[7
]}

Sandoval, Federico ^{[1
]}

Nizard, Mevyn ^{[1
]}

Quintin-Colonna, Francoise ^{[1
,8
]}

Kroemer, Guido ^{[9
,10
,11
,12
,13
]}

Fridman, Wolf H. ^{[3
,14
]}

Zitvogel, Laurence ^{[15
,16
]}

Oudard, Stephane ^{[1
,17
]}

Tartour, Eric ^{[1
,14
]}

机构：

[1] Univ Paris 05, INSERM, PARCC Paris Cardiovasc Res Ctr, U970, Paris, France

[2] Hop Europeen Georges Pompidou, Microbiol Serv, Paris, France

[3] Univ Paris 05, Univ Paris 06, INSERM, Ctr Rech Cordeliers,U872, Paris, France

[4] Hop Europeen Georges Pompidou, AP HP, Serv Anat Pathol, Paris, France

[5] Univ Franche Comte, INSERM, CHU Besancon, UMR 645, F-25030 Besancon, France

[6] Ctr Eugene Marquis, Dept Biol Clin, UMR 6061, Rennes, France

[7] Univ Paris 05, Lab Rech Biochirurg, Paris, France

[8] Ecole Natl Vet dAlfort, Maisons Alfort, France

[9] INSERM, U848, Villejuif, France

[10] Inst Gustave Roussy, Villejuif, France

[11] Ctr Rech Cordeliers, Paris, France

[12] Hop Europeen Georges Pompidou, AP HP, Paris, France

[13] Univ Paris 05, Fac Med, Paris, France

[14] Hop Europeen Georges Pompidou, Serv Immunol Biol, Paris, France

[15] Inst Gustave Roussy, INSERM, U1015, F-94805 Villejuif, France

[16] Ctr Clin Invest CBT507, Villejuif, France

[17] Hop Europeen Georges Pompidou, Med Oncol Serv, Paris, France

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 03期

关键词：

regulatory T cell; antiangiogenic molecule; CCR4; chemokine; DENDRITIC CELLS; TOLL-LIKE; IMMUNE-RESPONSES; TUMOR-IMMUNITY; PROGNOSTIC VALUE; RECEPTOR; INDUCTION; MELANOMA; EFFICACY; ANTIGEN;

D O I：

10.4161/onci.18852

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) have emerged as a dominant T cell population inhibiting anti-tumor effector T cells. Initial strategies used for Treg-depletion (cyclophosphamide, anti-CD25 mAb ...) also targeted activated T cells, as they share many phenotypic markers. Current, ameliorated approaches to inhibit Treg aim to either block their function or their migration to lymph nodes and the tumor microenvironment. Various drugs originally developed for other therapeutic indications (anti-angiogenic molecules, tyrosine kinase inhibitors, etc) have recently been discovered to inhibit Treg. These approaches are expected to be rapidly translated to clinical applications for therapeutic use in combination with immunomodulators.

引用

页码：326 / 333

页数：8

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