Rejuvenating exhausted T cells during chronic viral infection

被引：41

作者：

Okazaki, T ^{[1
]}

Honjo, T

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Immunol & Genom Med, Sakyo Ku, Kyoto 6068501, Japan

[2] Kyoto Univ, Grad Sch Med, Century COE Format 21st, Sakyo Ku, Kyoto 6068501, Japan

来源：

CELL | 2006年 / 124卷 / 03期

关键词：

D O I：

10.1016/j.cell.2006.01.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a recent paper in Nature, Barber et al. (2005) show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load.

引用

页码：459 / 461

页数：3

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