Connexins in cancer: bridging the gap to the clinic

被引：167

作者：

Aasen, Trond ^{[1
]}

Leithe, Edward ^{[2
,3
]}

Graham, Sheila V. ^{[4
]}

Kameritsch, Petra ^{[5
,6
]}

Mayan, Maria D. ^{[7
]}

Mesnil, Marc ^{[8
]}

Pogoda, Kristin ^{[5
,6
]}

Tabernero, Arantxa ^{[9
]}

机构：

[1] Autonomous Univ Barcelona, CIBERONC, Vall dHebron Inst Res VHIR, Translat Mol Pathol, Barcelona, Spain

[2] Oslo Univ Hosp, Inst Canc Res, Dept Mol Oncol, Oslo, Norway

[3] Oslo Univ Hosp, KG Jebsen Colorectal Canc Res Ctr, Oslo, Norway

[4] Univ Glasgow, Coll Med Vet & Life Sci, Inst Infect Immun & Inflammat, MRC,Ctr Virus Res, Glasgow, Lanark, Scotland

[5] Ludwig Maximilians Univ Munchen, Walter Brendel Ctr Expt Med, Munich, Germany

[6] Munich Univ Hosp, Munich, Germany

[7] Univ A Coruna, Serv Galego Saude SERGAS, Inst Invest Biomed A Coruna INIBIC, CellCOM Res Grp, La Coruna, Spain

[8] Univ Poitiers, Fac Sci Fondamentales & Appl, STIM Lab, Poitiers, France

[9] Univ Salamanca, INCYL, Dept Bioquim & Biol Mol, Salamanca, Spain

来源：

ONCOGENE | 2019年 / 38卷 / 23期

基金：

英国医学研究理事会;

关键词：

TRANS-RETINOIC ACID; SUICIDE-GENE-THERAPY; JUNCTIONAL INTERCELLULAR COMMUNICATION; HUMAN PROSTATE-CANCER; TUMOR-CELLS; BREAST-CANCER; UP-REGULATION; IN-VITRO; SPONTANEOUS METASTASIS; MONOCLONAL-ANTIBODIES;

D O I：

10.1038/s41388-019-0741-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and provide for the direct communication between adjacent cells. This type of intercellular communication permits the coordination of cellular activities and plays key roles in the control of cell growth and differentiation and in the maintenance of tissue homoeostasis. After more than 50 years, deciphering the links among connexins, gap junctions and cancer, researchers are now beginning to translate this knowledge to the clinic. The emergence of new strategies for connexin targeting, combined with an improved understanding of the molecular bases underlying the dysregulation of connexins during cancer development, offers novel opportunities for clinical applications. However, different connexin isoforms have diverse channel-dependent and -independent functions that are tissue and stage specific. This can elicit both pro- and anti-tumorigenic effects that engender significant challenges in the path towards personalised medicine. Here, we review the current understanding of the role of connexins and gap junctions in cancer, with particular focus on the recent progress made in determining their prognostic and therapeutic potential.

引用

页码：4429 / 4451

页数：23

共 224 条

[1]

The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progression [J].