Biocatalysis for Pharmaceuticals-Status and Prospects for a Key Technology

被引：53

作者：

Buckland, Barry C. ^{[1
]}

Robinson, David K. ^{[1
]}

Chartrain, Michel ^{[1
]}

机构：

[1] Merck Res Labs, Bioproc R&D, Rahway, NJ 07065 USA

来源：

METABOLIC ENGINEERING | 2000年 / 2卷 / 01期

关键词：

D O I：

10.1006/mben.1999.0138

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In reviewing how biocatalysis can be applied to improve chiral synthesis for pharmaceuticals it becomes clear that there will be many opportunities using a simple enzyme system but that many of the more useful applications will require the whole cell because of the requirement for cofactors. An assessment is made of the opportunities to apply metabolic engineering to construct de nova metabolic pathways for the biosynthesis of useful advanced intermediates and a conceptual example is provided for the biosynthesis of cis-aminoindanol. We predict that in the future novel pathways will be assembled for a one-step biosynthesis of many semisynthetic natural products. (C) 2000 Academic Press

引用

页码：42 / 48

页数：7

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