Synthesis of the C29-C37 segment of spongistatin 1

被引：21

作者：

Dunkel, R ^{[1
]}

Treu, J ^{[1
]}

Hoffmann, HMR ^{[1
]}

机构：

[1] Leibniz Univ Hannover, Dept Organ Chem, D-30167 Hannover, Germany

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(99)00148-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Starting from racemic 2 alpha-methyl-8-oxabicyclo[3.2.1]oct-6-en-3-one the spongistatin E segment has been prepared in nine steps (2.3 steps per stereogenic center) with umpolung of anomeric reactivity at C37. This 3,5-syn-diol sequence completes our methodology to all stereoisomers of 3,5,7-trihydroxy heptanoic ester building blocks functionalized for alpha-oxyanion chemistry. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1539 / 1549

页数：11

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