TIMs: central regulators of immune responses

被引：57

作者：

Hafler, David A. ^{[1
]}

Kuchroo, Vijay ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 12期

关键词：

D O I：

10.1084/jem.20082429

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Exhaustion of T cell responses during chronic viral infections has been observed in both mouse and man and has been attributed to up-regulation of PD-1 on the surface of exhausted T cells. In patients with chronic human HIV infection, T cell exhaustion leads to opportunistic infections associated with AIDS. However, not all the exhausted T cells express PD-1, suggesting that other molecules may be involved in the phenotype. A new study now demonstrates a central role for T cell immunoglobulin and mucin domain-containing protein-3 (TIM-3) in T cell exhaustion during chronic HIV infection and suggests that TIM-3 may be a novel therapeutic target in chronic viral diseases.

引用

页码：2699 / 2701

页数：3

共 21 条

[1] Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells [J].

Anderson, Ana C. ;

Anderson, David E. ;

Bregoli, Lisa ;

Hastings, William D. ;

Kassam, Nasim ;

Lei, Charles ;

Chandwaskar, Rucha ;

Karman, Jozsef ;

Su, Ee W. ;

Hirashima, Mitsuomi ;

Bruce, Jeffrey N. ;

Kane, Lawrence P. ;

Kuchroo, Vijay K. ;

Hafler, David A. .

SCIENCE, 2007, 318 (5853) :1141-1143

[2] Restoring function in exhausted CD8 T cells during chronic viral infection [J].

Barber, DL ;

Wherry, EJ ;

Masopust, D ;

Zhu, BG ;

Allison, JP ;

Sharpe, AH ;

Freeman, GJ ;

Ahmed, R .

NATURE, 2006, 439 (7077) :682-687

[3] T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface [J].

Cao, Erhu ;

Zang, Xingxing ;

Ramagopal, Udupi A. ;

Mukhopadhaya, Arunika ;

Fedorov, Alexander ;

Fedorov, Elena ;

Zencheck, Wendy D. ;

Lary, Jeffrey W. ;

Cole, James L. ;

Deng, Haiteng ;

Xiao, Hui ;

DiLorenzo, Teresa P. ;

Allison, James P. ;

Nathenson, Stanley G. ;

Almo, Haiteng C. .

IMMUNITY, 2007, 26 (03) :311-321

[4] PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression [J].

Day, Cheryl L. ;

Kaufmann, Daniel E. ;

Kiepiela, Photini ;

Brown, Julia A. ;

Moodley, Eshia S. ;

Reddy, Sharon ;

Mackey, Elizabeth W. ;

Miller, Joseph D. ;

Leslie, Alasdair J. ;

DePierres, Chantal ;

Mncube, Zenele ;

Duraiswamy, Jaikumar ;

Zhu, Baogong ;

Eichbaum, Quentin ;

Altfeld, Marcus ;

Wherry, E. John ;

Coovadia, Hoosen M. ;

Goulder, Philip J. R. ;

Klenerman, Paul ;

Ahmed, Rafi ;

Freeman, Gordon J. ;

Walker, Bruce D. .

NATURE, 2006, 443 (7109) :350-354

[5]

Hay C, 1998, AIDS Clin Care, V10, P1

[6] Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection [J].

Jones, R. Brad ;

Ndhlovu, Lishomwa C. ;

Barbour, Jason D. ;

Sheth, Prameet M. ;

Jha, Aashish R. ;

Long, Brian R. ;

Wong, Jessica C. ;

Satkunarajah, Malathy ;

Schweneker, Marc ;

Chapman, Joan M. ;

Gyenes, Gabor ;

Vali, Bahareh ;

Hyrcza, Martin D. ;

Yue, Feng Yun ;

Kovacs, Colin ;

Sassi, Aref ;

Loutfy, Mona ;

Halpenny, Roberta ;

Persad, Desmond ;

Spotts, Gerald ;

Hecht, Frederick M. ;

Chun, Tae-Wook ;

McCune, Joseph M. ;

Kaul, Rupert ;

Rini, James M. ;

Nixon, Douglas F. ;

Ostrowski, Mario A. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (12) :2763-2779

[7] Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus [J].

Kaplan, G ;

Totsuka, A ;

Thompson, P ;

Akatsuka, T ;

Moritsugu, Y ;

Feinstone, SM .

EMBO JOURNAL, 1996, 15 (16) :4282-4296

[8] Dysregulated T cell expression of TIM3 in multiple sclerosis [J].

Koguchi, Ken ;

Anderson, David E. ;

Yang, Li ;

O'Connor, Kevin C. ;

Kuchroo, Vijay K. ;

Hafler, David A. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (06) :1413-1418

[9] The TIM gene family:: Emerging roles in immunity and disease [J].

Kuchroo, VK ;

Umetsu, DT ;

DeKruyff, RH ;

Freeman, GJ .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (06) :454-462

[10] TIM-1, a novel allergy and asthma susceptibility gene [J].

McIntire, JJ ;

Umetsu, DT ;

DeKruyff, RH .

SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 2004, 25 (3-4) :335-348

← 1 2 3 →