Wolbachia- and Onchocerca volvulus-induced keratitis (River blindness) is dependent on myeloid differentiation factor 88

被引：21

作者：

Gillette-Ferguson, I

Hise, AG

Sun, Y

Diaconu, E

McGarry, HF

Taylor, MJ

Pearlman, E

机构：

[1] Case Western Reserve Univ, Dept Ophthalmol, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA

[3] Univ Liverpool Liverpool Sch Trop Med, Filariasis Res Lab, Liverpool L3 5QA, Merseyside, England

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.74.4.2442-2445.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Endosymbiotic Wolbachia bacteria that infect the filarial nematode Onchocerca volvulus were previously found to have an essential role in the pathogenesis of river blindness. The current study demonstrates that corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely dependent on expression of myeloid differentiation factor 88.

引用

收藏

页码：2442 / 2445

页数：4

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