Sex Difference in Oxytocin-Induced Anti-Hyperalgesia at the Spinal Level in Rats with Intraplantar Carrageenan-Induced Inflammation

被引：26

作者：

Chow, Lok-Hi ^{[2
,3
,4
]}

Chen, Yuan-Hao ^{[5
]}

Wu, Wan-Chuan ^{[1
]}

Chang, En-Pei ^{[1
]}

Huang, Eagle Yi-Kung ^{[1
]}

机构：

[1] Natl Def Med Ctr, Dept Pharmacol, Taipei, Taiwan

[2] Natl Def Med Ctr, Dept Anesthesiol, Taipei, Taiwan

[3] Taipei Vet Gen Hosp, Dept Anesthesiol, Taipei, Taiwan

[4] Natl Yang Ming Univ, Sch Med, Dept Anesthesiol, Taipei, Taiwan

[5] Natl Def Med Ctr, Tri Serv Gen Hosp, Dept Neurol Surg, Taipei, Taiwan

来源：

PLOS ONE | 2016年 / 11卷 / 09期

关键词：

ANGIOTENSIN-IV; MORPHINE ANTINOCICEPTION; ELECTRICAL-STIMULATION; CEREBROSPINAL-FLUID; INDUCED ANALGESIA; OPIOID RECEPTORS; CORD; PAIN; AMINOPEPTIDASE; MICE;

D O I：

10.1371/journal.pone.0162218

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Previously, we demonstrated intrathecal administration of oxytocin strongly induced anti-hyperalgesia in male rats. By using an oxytocin-receptor antagonist (atosiban), the descending oxytocinergic pathway was found to regulate inflammatory hyperalgesia in our previous study using male rats. The activity of this neural pathway is elevated during hyperalgesia, but whether this effect differs in a sex-dependent manner remains unknown. We conducted plantar tests on adult male and female virgin rats in which paw inflammation was induced using carrageenan. Exogenous (i.t.) application of oxytocin exerted no anti-hyperalgesic effect in female rats, except at an extremely high dose. Female rats exhibited similar extent of hyperalgesia to male rats did when the animals received the same dose of carrageenan. When atosiban was administered alone, the severity of hyperalgesia was not increased in female rats. Moreover, insulin-regulated aminopeptidase (IRAP) was expressed at higher levels in the spinal cords of female rats compared with those of male rats. Oxytocin-induced anti-hyperalgesia exhibits a sex-dependent difference in rats. This difference can partially result from the higher expression of IRAP in the spinal cords of female rats, because IRAP functions as an enzyme that degrades oxytocin. Our study confirms the existence of a sex difference in oxytocin-induced anti-hyperalgesia at the spinal level in rats.

引用

页数：15

共 35 条

[1]

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