Interleukin-10 Production in Response to Amyloid-β Differs between Slow and Fast Decliners in Patients with Alzheimer's Disease

被引：27

作者：

Asselineau, Delphine ^{[1
,2
,3
]}

Benlhassan, Khadija ^{[1
]}

Arosio, Beatrice ^{[4
,5
]}

Mari, Daniela ^{[4
,5
]}

Ferri, Evelyn ^{[4
]}

Casati, Martina ^{[4
]}

Gussago, Cristina ^{[4
]}

Tedone, Enzo ^{[4
]}

Annoni, Giorgio ^{[6
]}

Mazzola, Paolo ^{[6
]}

Piette, Francois ^{[7
]}

Belmin, Joel ^{[7
]}

Pariel, Sylvie ^{[7
]}

Bornand, Anne ^{[7
]}

Beaudeux, Jean-Louis ^{[8
,9
]}

Doulazmi, Mohamed ^{[2
,3
,7
]}

Mariani, Jean ^{[2
,3
,7
]}

Bray, Dorothy H. ^{[1
]}

机构：

[1] ImmunoClin Ltd, London, England

[2] Univ Paris 06, UMR Biol Adaptat & Ageing Team Brain Dev Repair &, Paris, France

[3] CNRS, UMR Biol Adaptat & Ageing Team Brain Dev Repair &, Paris, France

[4] Univ Milan, Dept Med Sci & Community Hlth, Geriatr Unit, Milan, Italy

[5] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Geriatr Unit, Milan, Italy

[6] Univ Milano Bicocca, Milan Ctr Neurosci, Geriatr Clin, Dept Hlth Sci, Milan, Italy

[7] DHU FAST GH Pitie Salpetriere Charles Foix, AP HP, Paris, France

[8] Paris Descartes, UMR S Pathophysiol & Pharmacotoxicol Human Placen, Fac Pharm, Paris, France

[9] Hop Necker Enfants Malad, AP HP, Dept Med Biochem, Paris, France

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 46卷 / 04期

关键词：

Alzheimer's disease; disease progression; IFN-gamma; interleukin-6; interleukin-10; peripheral blood mononuclear cells; single nucleotide polymorphisms; SINGLE NUCLEOTIDE POLYMORPHISM; CORONARY-HEART-DISEASE; IFN-GAMMA GENE; PROMOTER POLYMORPHISM; CYTOKINE PRODUCTION; INTERFERON-GAMMA; IMMUNE-RESPONSES; 1ST INTRON; RISK; ASSOCIATION;

D O I：

10.3233/JAD-142832

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

We investigated IL-10 and IL-6 production in amyloid-beta (A beta) stimulated peripheral blood mononuclear cells (PBMCs) in twenty Alzheimer's disease (AD) patients with slow progression, eleven with fast progression, and twenty age-matched controls. Promoter polymorphisms in IL-10 (position -592, -819, -1082), IL-6 (-174), transforming growth factor-beta 1 (TGF-beta 1) (-10, -25), interferon-beta (IFN-gamma) (-874), and tumor necrosis factor-alpha (TNF-alpha) (-308) genes were analyzed. IL-10 production after A beta stimulation was high in PBMCs from slow decliners and almost completely abrogated in fast decliners. Association between AA IFN-gamma low-producing genotype and fast progression was demonstrated. Investigations in a larger sample will clarify these findings.

引用

页码：837 / 842

页数：6

共 41 条

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