Low-density lipoprotein-antioxidant constituents of Saururus chinensis

被引：44

作者：

Ahn, BT

Lee, S

Lee, SB

Lee, ES

Kim, JG

Bok, SH

Jeong, TS

机构：

[1] Korea Res Inst Biosci & Biotechnol, Cardiovasc Res Lab, Taejon 305600, South Korea

[2] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 12期

关键词：

D O I：

10.1021/np0006061

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new diarylbutane lignan, saururin A (1), and a known 8-O-4'-type neolignan, machilin D (2), were isolated from a total methanol extract of the underground parts of Saururus chinensis. The structures of 1 and 2 were elucidated by spectroscopic data analysis. Compounds 1, 2, and virolin (3) (the methyl ether of 2) exhibited significant low-density lipoprotein (LDL)-antioxidant activity in the thiobarbituric acid-reactive substance (TBARS) assay with IC50 values of 8.5, 2.9, and 4.3 muM, respectively.

引用

页码：1562 / 1564

页数：3

共 19 条

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[Anonymous], 1999, Comprehensive Natural Products Chemistry

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Buege J A, 1978, Methods Enzymol, V52, P302

[3]

Chung BS, 1990, DICT KOREAN FOLK MED, P813

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