Comparative effects of well-balanced diets enriched in α-linolenic or linoleic acids on LC-PUFA metabolism in rat tissues

被引：50

作者：

Blanchard, H. ^{[1
]}

Pedrono, F. ^{[1
]}

Boulier-Monthean, N. ^{[1
]}

Catheline, D. ^{[1
]}

Rioux, V. ^{[1
]}

Legrand, P. ^{[1
]}

机构：

[1] Agrocampus Ouest, Lab Biochim & Nutr Humaine, INRA USC 2012, F-35042 Rennes, France

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2013年 / 88卷 / 05期

关键词：

Diet; Essential precursors; n-3 and n-6 PUFA; Desaturases; POLYUNSATURATED FATTY-ACIDS; DOCOSAHEXAENOIC ACID; FISH OILS; N-3; PUFA; LIVER; HEART; BRAIN; CONVERSION; DISEASE; RISK;

D O I：

10.1016/j.plefa.2013.03.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The intake of the essential fatty acid precursor alpha-linolenic acid (ALA) contributes to ensure adequate n-3 long-chain polyunsaturated fatty acid (LC-PUFA) bioavailability. Conversely, linoleic acid (LA) intake may compromise tissue n-3 PUFA status as its conversion to n-6 LC-PUFA shares a common enzymatic pathway with the n-3 family. This study aimed to measure dietary ALA and LA contribution to LC-PUFA biosynthesis and tissue composition. Rats were fed with control or experimental diets moderately enriched in ALA or LA for 8 weeks. Liver Delta 6- and Delta 5-desaturases were analyzed and FA composition was determined in tissues (red blood cells, liver, brain and heart). Hepatic Delta 6-desaturase activity was activated with both diets, and Delta 5-desaturase activity only with the ALA diet. The ALA diet led to higher n-3 LC-PUFA composition, including DHA in brain and heart. The LA diet reduced n-3 content in blood, liver and heart, without impacting n-6 LC-PUFA composition. At levels relevant with human nutrition, increasing dietary ALA and reducing LA intake were both beneficial in increasing n-3 LC-PUFA bioavailability in tissues. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：383 / 389

页数：7

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