XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells

被引：31

作者：

Carter, Bing Z. ^{[1
]}

Mak, Duncan H. ^{[1
]}

Wang, Zhiqiang ^{[2
]}

Ma, Wencai ^{[2
]}

Mak, Po Yee ^{[1
]}

Andreeff, Michael ^{[1
]}

Davis, R. Eric ^{[2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Sect Mol Hematol & Therapy, Dept Leukemia, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA

来源：

LEUKEMIA RESEARCH | 2013年 / 37卷 / 08期

基金：

美国国家卫生研究院;

关键词：

XIAP; Proteasome; Gene expression; AML; Caspase; I kappa B alpha; GENE-EXPRESSION DATA; X-LINKED INHIBITOR; FACTOR-KAPPA-B; STRUCTURAL BASIS; APOPTOSIS; ACTIVATION; DEFICIENCY; MECHANISM; DEATH; IAPS;

D O I：

10.1016/j.leukres.2013.04.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

To further understand the role of XIAP in acute myeloid leukemia (AML), we suppressed XIAP expression by antisense oligonucleotides and determined the effect on gene expression profiles and biological pathways. XIAP inhibition upregulated expression of proteasome genes in a manner similar to the proteasome inhibitor bortezomib or MG132; decreased 20S proteasome activity, an effect which was diminished in the presence of a pan-caspase inhibitor; and increased I kappa B alpha, Mcl-1, and HSP70 in AML cells. In addition to multiple functions already described, XIAP contributes to increased proteasome activity in AML cells, and the antitumor effect of XIAP inhibition may be mediated in part through caspase-dependent proteasome inhibition. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：974 / 979

页数：6

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