Association Between Body Mass Index and Mildly Decreased Estimated Glomerular Filtration Rate in Chinese Adults With Early Chronic Kidney Disease

Objectives: The magnitude of the influence that obesity contributes to the early stage of chronic kidney disease, especially among Asian population with higher obesity-related health risk, is unclear. The aim of this study was to investigate the association between body mass index (BMI) and mildly decreased estimated glomerular filtration rate (eGFR) among Chinese population. Design and Methods: A cross-sectional study was conducted among 1,100 subjects under health screenings. BMI was used to classify overweight and obesity as a BMI greater than or equal to 23.0 kg/m(2) and 25.0 kg/m(2), respectively. Mildly decreased eGFR was defined as 60.0 to <= 89.0 mL/min/1.73m(2) based on modification of diet in renal disease Chinese equation. Results: The prevalence of mildly decreased eGFR was increased significantly with increasing BMI categories. According to modification of diet in renal disease Chinese equation, obesity (odds ratio, 1.83; 95% confidence interval: 1.15-2.90) was positively associated with the odds of mildly decreased eGFR in the multivariate logistic regression model. BMI was significantly and negatively related to eGFR, and each increase in BMI (1.0 kg/m(2)) was associated with a decline in eGFR of 0.5 mL/min/1.73m(2). In subgroup analyses, BMI remained associated with an increased likelihood of mildly decreased eGFR independent of hypertension and diabetes. Conclusions: There was a positive relationship between BMI and mildly decreased eGFR among Chinese adults. Higher BMI may play a role in the onset and progression of renal damage, and maintaining a BMI in the healthy range may be contributed to the prevention of chronic kidney disease. (C) 2016 by the National Kidney Foundation, Inc. All rights reserved.