Effect of Intestinal Microbial Ecology on the Developing Brain

被引：155

作者：

Douglas-Escobar, Martha ^{[1
]}

Elliott, Elizabeth ^{[1
]}

Neu, Josef ^{[1
]}

机构：

[1] Univ Florida, Dept Pediat, Div Neonatol, Gainesville, FL 32610 USA

来源：

JAMA PEDIATRICS | 2013年 / 167卷 / 04期

关键词：

GUT MICROBIOTA; COLONIZATION; HEALTH; RECOGNITION; ACTIVATION; INFECTION; RESPONSES; BEHAVIOR; DISEASE; INFANCY;

D O I：

10.1001/jamapediatrics.2013.497

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

he mammalian gastrointestinal tract harbors a highly diverse microbial population that plays a major role in nutrition, metabolism, protection against pathogens, and development of the immune system. It is estimated that at least 1000 different bacterial species cohabit the human intestinal tract. Most recently, the Human Microbiome Project, using new genomic technologies, has started a catalog of specific microbiome composition and its correlation with health and specific diseases. Herein we provide a brief review of the intestinal microbiome, with a focus on new studies showing that there is an important link between the microbes that inhabit the intestinal tract and the developing brain. With future research, an understanding of this link may help us to treat various neurobehavioral problems such as autism, schizophrenia, and anxiety.

引用

页码：374 / 379

页数：6

共 45 条

[1]

Adamson J, 2011, BMC HEALTH SERV RES, V11, DOI [10.1186/1472-6963-11-218, 10.1186/1471-2431-11-111]

[2] Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut [J].

Artis, David .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (06) :411-420

[3] Mechanisms underlying the resistance to diet-induced obesity in germ-free mice [J].

Backhed, Fredrik ;

Manchester, Jill K. ;

Semenkovich, Clay F. ;

Gordon, Jeffrey I. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :979-984

[4] Microbes and the gut-brain axis [J].

Bercik, P. ;

Collins, S. M. ;

Verdu, E. F. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2012, 24 (05) :405-413

[5] The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice [J].

Bercik, Premysl ;

Denou, Emmanuel ;

Collins, Josh ;

Jackson, Wendy ;

Lu, Jun ;

Jury, Jennifer ;

Deng, Yikang ;

Blennerhassett, Patricia ;

Macri, Joseph ;

McCoy, Kathy D. ;

Verdu, Elena F. ;

Collins, Stephen M. .

GASTROENTEROLOGY, 2011, 141 (02) :599-U701

[6] Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve [J].

Bravo, Javier A. ;

Forsythe, Paul ;

Chew, Marianne V. ;

Escaravage, Emily ;

Savignac, Helene M. ;

Dinan, Timothy G. ;

Bienenstock, John ;

Cryan, John F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (38) :16050-16055

[7] Epigenetic mechanisms elicited by nutrition in early life [J].

Canani, Roberto Berni ;

Di Costanzo, Margherita ;

Leone, Ludovica ;

Bedogni, Giorgio ;

Brambilla, Paolo ;

Cianfarani, Stefano ;

Nobili, Valerio ;

Pietrobelli, Angelo ;

Agostoni, Carlo .

NUTRITION RESEARCH REVIEWS, 2011, 24 (02) :198-205

[8]

Chow J, 2010, ADV IMMUNOL, V107, P243, DOI [10.1016/S0065-2776(10)07001-X, 10.1016/B978-0-12-381300-8.00008-3]

[9] Bacterial colonization and gut development in preterm neonates [J].

Cilieborg, Malene S. ;

Boye, Mette ;

Sangild, Per T. .

EARLY HUMAN DEVELOPMENT, 2012, 88 :S41-S49

[10] Prolonged Duration of Initial Empirical Antibiotic Treatment Is Associated With Increased Rates of Necrotizing Enterocolitis and Death for Extremely Low Birth Weight Infants [J].

Cotten, C. Michael ;

Taylor, Sarah ;

Stoll, Barbara ;

Goldberg, Ronald N. ;

Hansen, Nellie I. ;

Sanchez, Pablo J. ;

Ambalavanan, Namasivayam ;

Benjamin, Daniel K., Jr. .

PEDIATRICS, 2009, 123 (01) :58-66

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