Reduction of dyskinesia and induction of akinesia induced by morphine in two Parkinsonian patients with severe sciatica

被引：41

作者：

Berg, D ^{[1
]}

Becker, G ^{[1
]}

Reiners, K ^{[1
]}

机构：

[1] Univ Wurzburg, Neurol Klin, Dept Neurol, D-97080 Wurzburg, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 1999年 / 106卷 / 7-8期

关键词：

morphine; Parkinson's disease; dyskinesia; akinesia; modulation; basal ganglia output;

D O I：

10.1007/s007020050192

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In two patients with Parkinson's disease and L-Dopa induced dyskinesia we administered morphine orally to alleviate lumboradicular pain unresponsive to any other form of treatment. Besides an alleviation of the pain both patients showed a decrease in dyskinetic movements at very low doses of morphine and an increase in akinesia at higher doses. This observation indicates a modulation of basal ganglia output by morphine with the possibility of reducing L-Dopa induced dyskinesia in patients treated with morphine for pain.

引用

页码：725 / 728

页数：4

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