Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy

被引：105

作者：

Vandergriff, Adam C. ^{[1
,2
,3
]}

de Andrade, James Bizetto Meira ^{[1
]}

Tang, Junnan ^{[1
,4
]}

Hensley, M. Taylor ^{[1
]}

Piedrahita, Jorge A. ^{[1
]}

Caranasos, Thomas G. ^{[5
]}

Cheng, Ke ^{[1
,2
,3
,6
]}

机构：

[1] N Carolina State Univ, Coll Vet Med, Mol Biomed Sci, Raleigh, NC 27695 USA

[2] Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC 27599 USA

[3] NC State Univ, Raleigh, NC 27695 USA

[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Cardiol, Coll Med, Zhengzhou 450052, Henan, Peoples R China

[5] Univ N Carolina, Div Cardiothorac Surg, Chapel Hill, NC 27599 USA

[6] Soochow Univ, Cyrus Tang Hematol Ctr, Suzhou 215123, Peoples R China

来源：

STEM CELLS INTERNATIONAL | 2015年 / 2015卷

基金：

中国国家自然科学基金;

关键词：

EXTRACELLULAR VESICLES; REGENERATION; EFFICACY; DELIVERY; THERAPY; AGENTS;

D O I：

10.1155/2015/960926

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Despite the efficacy of cardiac stem cells (CSCs) for treatment of cardiomyopathies, there are many limitations to stem cell therapies. CSC-derived exosomes (CSC-XOs) have been shown to be responsible for a large portion of the regenerative effects of CSCs. Using a mouse model of doxorubicin induced dilated cardiomyopathy, we study the effects of systemic delivery of human CSC-XOs in mice. Mice receiving CSC-XOs showed improved heart function via echocardiography, as well as decreased apoptosis and fibrosis. In spite of using immunocompetent mice and human CSC-XOs, mice showed no adverse immune reaction. The use of CSC-XOs holds promise for overcoming the limitations of stem cells and improving cardiac therapies.

引用

页数：8

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