VEGF targets the tumour cell

被引：1150

作者：

Goel, Hira Lal ^{[1
]}

Mercurio, Arthur M. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA 01655 USA

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 12期

基金：

美国国家卫生研究院;

关键词：

ENDOTHELIAL-GROWTH-FACTOR; AUTOCRINE SURVIVAL FACTOR; HUMAN PANCREATIC-CANCER; LYMPH-NODE METASTASIS; BREAST-CANCER; FACTOR-C; FACTOR RECEPTOR-3; PROGNOSTIC VALUE; CARCINOMA-CELLS; FACTOR-A;

D O I：

10.1038/nrc3627

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The function of vascular endothelial growth factor (VEGF) in cancer is not limited to angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells, and this signalling contributes to key aspects of tumorigenesis, including the function of cancer stem cells and tumour initiation. In addition to VEGF receptor tyrosine kinases, the neuropilins are crucial for mediating the effects of VEGF on tumour cells, primarily because of their ability to regulate the function and the trafficking of growth factor receptors and integrins. This has important implications for our understanding of tumour biology and for the development of more effective therapeutic approaches.

引用

页码：871 / 882

页数：12

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