Manipulation and overstretching of genes on solid substrates

被引：71

作者：

Severin, M

Barner, J

Kalachev, AA

Rabe, JP

机构：

[1] Humboldt Univ, Dept Phys, D-12489 Berlin, Germany

[2] Plasmachem GmbH, D-55128 Mainz, Germany

来源：

NANO LETTERS | 2004年 / 4卷 / 04期

关键词：

D O I：

10.1021/nl035147d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A "molecular chip", i.e., a chip on which single macromolecules are freely arranged, is a key for the fabrication of nanoscopic molecular devices, e.g., DNA molecular array chips. We report on a new method for the manipulation of already deposited single macromolecules, which allows to freely position single polyelectrolytes such as DNA on a substrate, to bend and stretch them, to remove stretching defects, and to overstretch double stranded DNA into two parallel single strands.

引用

收藏

页码：577 / 579

页数：3

相关论文

共 22 条

[1] ANISOTROPIC MOLECULAR-DYNAMICS IN THE VICINITY OF ORDER-DISORDER TRANSITIONS IN ORGANIC MONOLAYERS [J].

ASKADSKAYA, L ;

RABE, JP .

PHYSICAL REVIEW LETTERS, 1992, 69 (09) :1395-1398

[2] ALIGNMENT AND SENSITIVE DETECTION OF DNA BY A MOVING INTERFACE [J].

BENSIMON, A ;

SIMON, A ;

CHIFFAUDEL, A ;

CROQUETTE, V ;

HESLOT, F ;

BENSIMON, D .

SCIENCE, 1994, 265 (5181) :2096-2098

[3] Ten years of tension: single-molecule DNA mechanics [J].

Bustamante, C ;

Bryant, Z ;

Smith, SB .

NATURE, 2003, 421 (6921) :423-427

[4] SELF-ASSEMBLED ALKANE MONOLAYERS ON MOSE2 AND MOS2 [J].

CINCOTTI, S ;

RABE, JP .

APPLIED PHYSICS LETTERS, 1993, 62 (26) :3531-3533

[5] A vision for the future of genomics research [J].

Collins, FS ;

Green, ED ;

Guttmacher, AE ;

Guyer, MS .

NATURE, 2003, 422 (6934) :835-847

[6] POSITIONING SINGLE ATOMS WITH A SCANNING TUNNELING MICROSCOPE [J].

EIGLER, DM ;

SCHWEIZER, EK .

NATURE, 1990, 344 (6266) :524-526

[7] Nanoscale science of single molecules using local probes [J].

Gimzewski, JK ;

Joachim, C .

SCIENCE, 1999, 283 (5408) :1683-1688

[8] Surface structure characterization of DNA oligomer on Cu(111) surface using low temperature scanning tunneling microscopy [J].

Hamai, C ;

Tanaka, H ;

Kawai, T .

JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B, 1999, 17 (04) :1313-1316

[9] 2-DIMENSIONAL ORDERING OF THE DNA-BASE GUANINE OBSERVED BY SCANNING TUNNELING MICROSCOPY [J].

HECKL, WM ;

SMITH, DPE ;

BINNIG, G ;

KLAGGES, H ;

HANSCH, TW ;

MADDOCKS, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (18) :8003-8005

[10]

Hla SW, 2001, CHEMPHYSCHEM, V2, P361, DOI 10.1002/1439-7641(20010618)2:6<361::AID-CPHC361>3.0.CO