Redefining the minimal antigen-binding fragment

被引:60
作者
Sheriff, S
Constantine, KL
机构
来源
NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 09期
关键词
D O I
10.1038/nsb0996-733
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The X-ray structures of a lysozyme-complexed camel VH domain and an antigen-free Ilama VH domain reveal novel features that open up new possibilities for generating and engineering minimal antigen recognition units.
引用
收藏
页码:733 / 736
页数:4
相关论文
共 32 条
[1]   SEMISYNTHETIC COMBINATORIAL ANTIBODY LIBRARIES - A CHEMICAL SOLUTION TO THE DIVERSITY PROBLEM [J].
BARBAS, CF ;
BAIN, JD ;
HOEKSTRA, DM ;
LERNER, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4457-4461
[2]   A RECOMBINANT IMMUNOTOXIN CONTAINING A DISULFIDE-STABILIZED FV FRAGMENT [J].
BRINKMANN, U ;
REITER, Y ;
JUNG, SH ;
LEE, B ;
PASTAN, I .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (16) :7538-7542
[3]   RIBBONS 2 0 [J].
CARSON, M .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1991, 24 :958-&
[4]   CANONICAL STRUCTURES FOR THE HYPERVARIABLE REGIONS OF IMMUNOGLOBULINS [J].
CHOTHIA, C ;
LESK, AM .
JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (04) :901-917
[5]   DOMAIN ASSOCIATION IN IMMUNOGLOBULIN MOLECULES - THE PACKING OF VARIABLE DOMAINS [J].
CHOTHIA, C ;
NOVOTNY, J ;
BRUCCOLERI, R ;
KARPLUS, M .
JOURNAL OF MOLECULAR BIOLOGY, 1985, 186 (03) :651-663
[6]   STRUCTURAL REPERTOIRE OF THE HUMAN V(H) SEGMENTS [J].
CHOTHIA, C ;
LESK, AM ;
GHERARDI, E ;
TOMLINSON, IM ;
WALTER, G ;
MARKS, JD ;
LLEWELYN, MB ;
WINTER, G .
JOURNAL OF MOLECULAR BIOLOGY, 1992, 227 (03) :799-817
[7]  
COLMAN PM, 1988, ADV IMMUNOL, V43, P99
[8]   ANTIBODY-ANTIGEN COMPLEXES [J].
DAVIES, DR ;
PADLAN, EA ;
SHERIFF, S .
ANNUAL REVIEW OF BIOCHEMISTRY, 1990, 59 :439-473
[9]   Interactions of protein antigens with antibodies [J].
Davies, DR ;
Cohen, GH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :7-12
[10]   CAMELISING HUMAN-ANTIBODY FRAGMENTS - NMR-STUDIES ON VH DOMAINS [J].
DAVIES, J ;
RIECHMANN, L .
FEBS LETTERS, 1994, 339 (03) :285-290