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Redefining the minimal antigen-binding fragment
被引:60
作者
:
Sheriff, S
论文数:
0
引用数:
0
h-index:
0
Sheriff, S
Constantine, KL
论文数:
0
引用数:
0
h-index:
0
Constantine, KL
机构
:
来源
:
NATURE STRUCTURAL BIOLOGY
|
1996年
/ 3卷
/ 09期
关键词
:
D O I
:
10.1038/nsb0996-733
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
The X-ray structures of a lysozyme-complexed camel VH domain and an antigen-free Ilama VH domain reveal novel features that open up new possibilities for generating and engineering minimal antigen recognition units.
引用
收藏
页码:733 / 736
页数:4
相关论文
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SEMISYNTHETIC COMBINATORIAL ANTIBODY LIBRARIES - A CHEMICAL SOLUTION TO THE DIVERSITY PROBLEM
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LERNER, RA
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
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89
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:4457
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[2]
A RECOMBINANT IMMUNOTOXIN CONTAINING A DISULFIDE-STABILIZED FV FRAGMENT
[J].
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Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda
JUNG, SH
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LEE, B
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Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda
LEE, B
;
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PASTAN, I
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1993,
90
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[3]
RIBBONS 2 0
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CARSON, M
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0
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Univ of Alabama at Birmingham, Birmingham
CARSON, M
.
JOURNAL OF APPLIED CRYSTALLOGRAPHY,
1991,
24
:958
-&
[4]
CANONICAL STRUCTURES FOR THE HYPERVARIABLE REGIONS OF IMMUNOGLOBULINS
[J].
CHOTHIA, C
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UNIV LONDON UNIV COLL,CHRISTOPHER INGOLD LAB,LONDON WC1H 0AJ,ENGLAND
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[5]
DOMAIN ASSOCIATION IN IMMUNOGLOBULIN MOLECULES - THE PACKING OF VARIABLE DOMAINS
[J].
CHOTHIA, C
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0
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0
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UNIV LONDON UNIV COLL,DEPT CHEM,CHRISTOPHER INGOLD LABS,LONDON WC1H 0AJ,ENGLAND
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UNIV LONDON UNIV COLL,DEPT CHEM,CHRISTOPHER INGOLD LABS,LONDON WC1H 0AJ,ENGLAND
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:7
-12
[10]
CAMELISING HUMAN-ANTIBODY FRAGMENTS - NMR-STUDIES ON VH DOMAINS
[J].
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MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
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DAVIES, J
;
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引用数:
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h-index:
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机构:
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MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
RIECHMANN, L
.
FEBS LETTERS,
1994,
339
(03)
:285
-290
←
1
2
3
4
→
共 32 条
[1]
SEMISYNTHETIC COMBINATORIAL ANTIBODY LIBRARIES - A CHEMICAL SOLUTION TO THE DIVERSITY PROBLEM
[J].
BARBAS, CF
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS RES INST, DEPT CHEM, LA JOLLA, CA 92037 USA
SCRIPPS RES INST, DEPT CHEM, LA JOLLA, CA 92037 USA
BARBAS, CF
;
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0
引用数:
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h-index:
0
机构:
SCRIPPS RES INST, DEPT CHEM, LA JOLLA, CA 92037 USA
SCRIPPS RES INST, DEPT CHEM, LA JOLLA, CA 92037 USA
BAIN, JD
;
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h-index:
0
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SCRIPPS RES INST, DEPT CHEM, LA JOLLA, CA 92037 USA
HOEKSTRA, DM
;
LERNER, RA
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS RES INST, DEPT CHEM, LA JOLLA, CA 92037 USA
SCRIPPS RES INST, DEPT CHEM, LA JOLLA, CA 92037 USA
LERNER, RA
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1992,
89
(10)
:4457
-4461
[2]
A RECOMBINANT IMMUNOTOXIN CONTAINING A DISULFIDE-STABILIZED FV FRAGMENT
[J].
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论文数:
0
引用数:
0
h-index:
0
机构:
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BRINKMANN, U
;
REITER, Y
论文数:
0
引用数:
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h-index:
0
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;
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论文数:
0
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论文数:
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引用数:
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h-index:
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Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda
LEE, B
;
论文数:
引用数:
h-index:
机构:
PASTAN, I
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1993,
90
(16)
:7538
-7542
[3]
RIBBONS 2 0
[J].
CARSON, M
论文数:
0
引用数:
0
h-index:
0
机构:
Univ of Alabama at Birmingham, Birmingham
CARSON, M
.
JOURNAL OF APPLIED CRYSTALLOGRAPHY,
1991,
24
:958
-&
[4]
CANONICAL STRUCTURES FOR THE HYPERVARIABLE REGIONS OF IMMUNOGLOBULINS
[J].
CHOTHIA, C
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LONDON UNIV COLL,CHRISTOPHER INGOLD LAB,LONDON WC1H 0AJ,ENGLAND
CHOTHIA, C
;
LESK, AM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LONDON UNIV COLL,CHRISTOPHER INGOLD LAB,LONDON WC1H 0AJ,ENGLAND
LESK, AM
.
JOURNAL OF MOLECULAR BIOLOGY,
1987,
196
(04)
:901
-917
[5]
DOMAIN ASSOCIATION IN IMMUNOGLOBULIN MOLECULES - THE PACKING OF VARIABLE DOMAINS
[J].
CHOTHIA, C
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LONDON UNIV COLL,DEPT CHEM,CHRISTOPHER INGOLD LABS,LONDON WC1H 0AJ,ENGLAND
CHOTHIA, C
;
NOVOTNY, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LONDON UNIV COLL,DEPT CHEM,CHRISTOPHER INGOLD LABS,LONDON WC1H 0AJ,ENGLAND
NOVOTNY, J
;
BRUCCOLERI, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LONDON UNIV COLL,DEPT CHEM,CHRISTOPHER INGOLD LABS,LONDON WC1H 0AJ,ENGLAND
BRUCCOLERI, R
;
KARPLUS, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LONDON UNIV COLL,DEPT CHEM,CHRISTOPHER INGOLD LABS,LONDON WC1H 0AJ,ENGLAND
KARPLUS, M
.
JOURNAL OF MOLECULAR BIOLOGY,
1985,
186
(03)
:651
-663
[6]
STRUCTURAL REPERTOIRE OF THE HUMAN V(H) SEGMENTS
[J].
CHOTHIA, C
论文数:
0
引用数:
0
h-index:
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机构:
UNIV CAMBRIDGE,DEPT HAEMATOL,CAMBRIDGE CB2 2QH,ENGLAND
CHOTHIA, C
;
LESK, AM
论文数:
0
引用数:
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h-index:
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机构:
UNIV CAMBRIDGE,DEPT HAEMATOL,CAMBRIDGE CB2 2QH,ENGLAND
LESK, AM
;
GHERARDI, E
论文数:
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引用数:
0
h-index:
0
机构:
UNIV CAMBRIDGE,DEPT HAEMATOL,CAMBRIDGE CB2 2QH,ENGLAND
GHERARDI, E
;
TOMLINSON, IM
论文数:
0
引用数:
0
h-index:
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机构:
UNIV CAMBRIDGE,DEPT HAEMATOL,CAMBRIDGE CB2 2QH,ENGLAND
TOMLINSON, IM
;
WALTER, G
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CAMBRIDGE,DEPT HAEMATOL,CAMBRIDGE CB2 2QH,ENGLAND
WALTER, G
;
MARKS, JD
论文数:
0
引用数:
0
h-index:
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机构:
UNIV CAMBRIDGE,DEPT HAEMATOL,CAMBRIDGE CB2 2QH,ENGLAND
MARKS, JD
;
LLEWELYN, MB
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CAMBRIDGE,DEPT HAEMATOL,CAMBRIDGE CB2 2QH,ENGLAND
LLEWELYN, MB
;
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论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CAMBRIDGE,DEPT HAEMATOL,CAMBRIDGE CB2 2QH,ENGLAND
WINTER, G
.
JOURNAL OF MOLECULAR BIOLOGY,
1992,
227
(03)
:799
-817
[7]
COLMAN PM, 1988, ADV IMMUNOL, V43, P99
[8]
ANTIBODY-ANTIGEN COMPLEXES
[J].
DAVIES, DR
论文数:
0
引用数:
0
h-index:
0
机构:
SQUIBB INST MED RES, PRINCETON, NJ 08543 USA
SQUIBB INST MED RES, PRINCETON, NJ 08543 USA
DAVIES, DR
;
PADLAN, EA
论文数:
0
引用数:
0
h-index:
0
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SQUIBB INST MED RES, PRINCETON, NJ 08543 USA
SQUIBB INST MED RES, PRINCETON, NJ 08543 USA
PADLAN, EA
;
SHERIFF, S
论文数:
0
引用数:
0
h-index:
0
机构:
SQUIBB INST MED RES, PRINCETON, NJ 08543 USA
SQUIBB INST MED RES, PRINCETON, NJ 08543 USA
SHERIFF, S
.
ANNUAL REVIEW OF BIOCHEMISTRY,
1990,
59
:439
-473
[9]
Interactions of protein antigens with antibodies
[J].
Davies, DR
论文数:
0
引用数:
0
h-index:
0
机构:
Laboratory of Molecular Biology, Natl. Inst. Diabet., Digest. K., National Institutes of Health, Bethesda
Davies, DR
;
Cohen, GH
论文数:
0
引用数:
0
h-index:
0
机构:
Laboratory of Molecular Biology, Natl. Inst. Diabet., Digest. K., National Institutes of Health, Bethesda
Cohen, GH
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1996,
93
(01)
:7
-12
[10]
CAMELISING HUMAN-ANTIBODY FRAGMENTS - NMR-STUDIES ON VH DOMAINS
[J].
DAVIES, J
论文数:
0
引用数:
0
h-index:
0
机构:
MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
DAVIES, J
;
RIECHMANN, L
论文数:
0
引用数:
0
h-index:
0
机构:
MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
RIECHMANN, L
.
FEBS LETTERS,
1994,
339
(03)
:285
-290
←
1
2
3
4
→