The effects of level of expression of a jellyfish Shaker potassium channel:: a positive potassium feedback mechanism

被引:7
作者
Grigoriev, NG
Spafford, JD
Spencer, AN [1 ]
机构
[1] Bamfield Marine Stn, Bamfield, BC V0R 1B0, Canada
[2] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada
来源
JOURNAL OF PHYSIOLOGY-LONDON | 1999年 / 517卷 / 01期
关键词
D O I
10.1111/j.1469-7793.1999.0025z.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. When jellyfish Shaker potassium channels (jShak2) are heterologously expressed in Xenopus oocytes at different levels they demonstrate density-dependent changes in electrical and kinetic properties of macroscopic currents. 2. The activation and inactivation properties of jShak2 channels depend on the extracellular potassium concentration. In this study we present experimental data which show that expression-dependent changes in kinetic and electrical properties of jShak2 macroscopic currents can be explained by the positive feedback effect of dynamic accumulation of K+ in the perimembranal space.
引用
收藏
页码:25 / 33
页数:9
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