Macrophage stimulating protein may promote tubular regeneration after acute injury

被引：43

作者：

Cantaluppi, Vincenzo ^{[1
,2
]}

Biancone, Luigi ^{[1
,2
]}

Romanazzi, Giuseppe Mauriello ^{[1
]}

Figliolini, Federico ^{[1
]}

Beltramo, Silvia ^{[1
]}

Galimi, Francesco ^{[3
]}

Camboni, Maria Gavina ^{[3
]}

Deriu, Elisa ^{[3
]}

Conaldi, Piergiulio ^{[4
]}

Bottelli, Antonella ^{[5
]}

Orlandi, Viviana ^{[6
]}

Herrera, Maria Beatriz ^{[1
]}

Pacitti, Alfonso ^{[2
]}

Segoloni, Giuseppe Paolo ^{[2
]}

Camussi, Giovanni ^{[1
,2
]}

机构：

[1] Univ Turin, Dept Internal Med, Res Ctr Expt Med, Turin, Italy

[2] Univ Turin, Dept Internal Med, Nephrol Dialysis & Renal Transplantat Unit, Turin, Italy

[3] Univ Sassari, INBB, Dept Biomed Sci, I-07100 Sassari, Italy

[4] Univ Pittsburgh, Med Ctr, Lab Clin Pathol Microbiol & Virol, Mediterrarean Inst Transplantat & Adv Specialized, Palermo, Italy

[5] Univ Insubria, Dept Publ Hlth Med, Varese, Italy

[6] Univ Insubria, Dept Struct & Funct Biol, Varese, Italy

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 19卷 / 10期

关键词：

D O I：

10.1681/ASN.2007111209

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Macrophage-stimulating protein (MSP) exerts proliferative and antiapoptotic effects, suggesting that it may play a role in tubular regeneration after acute kidney injury. In this study, elevated plasma levels of MSP were found both in critically ill patients with acute renal failure and in recipients of renal allografts during the first week after transplantation. In addition, MSP and its receptor, RON, were markedly upregulated in the regenerative phase after glycerol-induced tubular injury in mice. In vitro, MSP stimulated tubular epithelial cell proliferation and conferred resistance to cisplatin-induced apoptosis by inhibiting caspase activation and modulating Fas, mitochondrial proteins, Akt, and extracellular signal-regulated kinase. MSP also enhanced migration, scattering, branching morphogenesis, tubulogenesis, and mesenchymal de-differentiation of surviving tubular cells. In addition, MSP induced an embryonic phenotype characterized by Pax-2 expression. In conclusion, MSP is upregulated during the regeneration of injured tubular cells, and it exerts multiple biologic effects that may aid recovery from acute kidney injury.

引用

页码：1904 / 1918

页数：15

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