The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

被引：645

作者：

Weber, Christian ^{[1
]}

Zernecke, Alma ^{[1
]}

Libby, Peter ^{[2
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Mol Cardiovasc Res, D-52074 Aachen, Germany

[2] Harvard Univ, Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 10期

关键词：

D O I：

10.1038/nri2415

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic inflammation drives the development of atherosclerosis, and details regarding the involvement of different leukocyte subpopulations in the pathology of this disease have recently emerged. This Review highlights the surprising contribution of granulocyte subsets and mast cells to early atherogenesis and subsequent plaque instability, and describes the complex, double-edged role of monocyte, macrophage and dendritic-cell subsets through crosstalk with T cells and vascular progenitor cells. Improved understanding of the selective contributions of specific cell types to atherogenesis will pave the way for new targeted approaches to therapy.

引用

页码：802 / 815

页数：14

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