Mechanism of protein biosynthesis in mammalian mitochondria

被引:134
作者
Christian, Brooke E. [1 ]
Spremulli, Linda L. [1 ]
机构
[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2012年 / 1819卷 / 9-10期
基金
美国国家卫生研究院;
关键词
Mammal; Mitochondrion; Protein synthesis; Initiation; Elongation; Termination; ELONGATION-FACTOR TS; INITIATION-FACTOR IF3; AMINOACYL-TRANSFER-RNA; INNER MEMBRANE-PROTEIN; SMALL RIBOSOMAL-SUBUNIT; TERMINATION CODONS UAA; HIGHER-ORDER STRUCTURE; C-OXIDASE DEFICIENCY; FACTOR EF-TU; ESCHERICHIA-COLI;
D O I
10.1016/j.bbagrm.2011.11.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Protein synthesis in mammalian mitochondria produces 13 proteins that are essential subunits of the oxidative phosphorylation complexes. This review provides a detailed outline of each phase of mitochondrial translation including initiation, elongation, termination, and ribosome recycling. The roles of essential proteins involved in each phase are described. All of the products of mitochondrial protein synthesis in mammals are inserted into the inner membrane. Several proteins that may help bind ribosomes to the membrane during translation are described, although much remains to be learned about this process. Mutations in mitochondrial or nuclear genes encoding components of the translation system often lead to severe deficiencies in oxidative phosphorylation, and a summary of these mutations is provided. This article is part of a Special Issue entitled: Mitochondrial Gene Expression. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:1035 / 1054
页数:20
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