CD 117 (KIT): A diverse protein with selective applications in surgical pathology

被引：61

作者：

Gibson, PC ^{[1
]}

Cooper, K ^{[1
]}

机构：

[1] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2002年 / 9卷 / 01期

关键词：

CD117; c-kit; gastrointestinal stromal tumor; immunohistochemistry;

D O I：

10.1097/00125480-200201000-00007

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

CD 117 (KIT) is a transmembrane, tyrosine kinase growth factor receptor which is expressed on numerous diverse fetal and adult cells including hematopoietic cells, mast cells, melanocytes, germ cells, and the interstitial cells of Cajal. Its expression in tumors is also diverse, but with selective use and attention to specific staining patterns, this marker is useful in the identification of gastrointestinal stromal tumors, mast cell tumors, and seminomatous germ cell tumors.

引用

页码：65 / 69

页数：5

共 54 条

[1] Paraffin section detection of the c-kit gene product (CD117) in human tissues:: Value in the diagnosis of mast cell disorders [J].

Arber, DA ;

Tamayo, R ;

Weiss, LM .

HUMAN PATHOLOGY, 1998, 29 (05) :498-504

[2] The biology of stem cell factor and its receptor C-kit [J].

Ashman, LK .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1999, 31 (10) :1037-1051

[3] Expression of the stem cell factor receptor c-kit in normal and diseased pediatric liver:: Identification of a human hepatic progenitor cell? [J].

Baumann, U ;

Crosby, HA ;

Ramani, P ;

Kelly, DA ;

Strain, AJ .

HEPATOLOGY, 1999, 30 (01) :112-117

[4] A NEW ACUTE TRANSFORMING FELINE RETROVIRUS AND RELATIONSHIP OF ITS ONCOGENE V-KIT WITH THE PROTEIN-KINASE GENE FAMILY [J].

BESMER, P ;

MURPHY, JE ;

GEORGE, PC ;

QIU, F ;

BERGOLD, PJ ;

LEDERMAN, L ;

SNYDER, HW ;

BRODEUR, D ;

ZUCKERMAN, EE ;

HARDY, WD .

NATURE, 1986, 320 (6061) :415-421

[5]

BLAKOLMER K, 1995, HEPATOLOGY, V21, P1115

[6] Expression of stem-cell factor and its receptor c-kit protein in normal testicular tissue and malignant germ-cell tumours [J].

Bokemeyer, C ;

Kuczyk, MA ;

Dunn, T ;

Serth, J ;

Hartmann, K ;

Jonasson, J ;

Pietsch, T ;

Jonas, U ;

Schmoll, HJ .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1996, 122 (05) :301-306

[7] Mesenchymal tumors of the gastrointestinal tract:: A paradise for acronyms (STUMP, GIST, GANT, and now GIPACT), implication of c-kit in genesis, and yet another of the many emerging roles of the interstitial cell of Cajal in the pathogenesis of gastrointestinal diseases? [J].

Chan, JKC .

ADVANCES IN ANATOMIC PATHOLOGY, 1999, 6 (01) :19-40

[8] CD34, CD117, and actin expression in phyllodes tumor of the breast [J].

Chen, CM ;

Chen, CJ ;

Chang, CL ;

Shyu, JS ;

Hsieh, HF ;

Harn, HJ .

JOURNAL OF SURGICAL RESEARCH, 2000, 94 (02) :84-91

[9] Immunohistochemical expression of the c-kit proto-oncogene product in human malignant and non-malignant breast tissues [J].

Chui, X ;

Egami, H ;

Yamashita, J ;

Kurizaki, T ;

Ohmachi, H ;

Yamamoto, S ;

Ogawa, M .

BRITISH JOURNAL OF CANCER, 1996, 73 (10) :1233-1236

[10] Human hepatic stem-like cells isolated using c-kit or CD34 can differentiate into biliary epithelium [J].

Crosby, HA ;

Kelly, DA ;

Strain, AJ .

GASTROENTEROLOGY, 2001, 120 (02) :534-544

← 1 2 3 4 5 6 →