The role of AMP-activated protein kinase in regulating white adipose tissue metabolism

被引：99

作者：

Ceddia, R. B. ^{[1
]}

机构：

[1] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 1P3, Canada

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2013年 / 366卷 / 02期

基金：

加拿大创新基金会;

关键词：

AMPK; Lipolysis; Obesity; Glucose uptake; Adipocyte; AS160; HORMONE-SENSITIVE LIPASE; FATTY-ACID OXIDATION; ISOLATED RAT ADIPOCYTES; ACETYL-COA CARBOXYLASE; SKELETAL-MUSCLE; 3T3-L1; ADIPOCYTES; GLUCOSE-UPTAKE; GLUT4; TRANSLOCATION; LIPID-METABOLISM; IN-VITRO;

D O I：

10.1016/j.mce.2012.06.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that plays a major role in the maintenance of energy homeostasis in various organs and tissues. When activated, AMPK can induce substrate catabolism and shut down energy-consuming anabolic pathways to increase intracellular ATP availability. Even though most of these effects have been described in muscle and liver, several studies have provided compelling evidence that AMPK also plays an important role in the regulation of white adipose tissue (WAT) glucose and lipid metabolism. In fact, the effects of acute and chronic AMPK activation in the WAT induce profound changes in adiposity with important implications for the treatment of obesity and its related metabolic disorders. This review discusses the role of AMPK in the regulation of white adipocyte metabolism with respect to energy storage and release, gene expression, mitochondrial biogenesis, oxidative capacity, cell differentiation, and the potential impact on whole-body adiposity and energy homeostasis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：194 / 203

页数：10

共 97 条

[1]

Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype [J].

Ahmadian, Maryam ;

Abbott, Marcia J. ;

Tang, Tianyi ;

Hudak, Carolyn S. S. ;

Kim, Yangha ;

Bruss, Matthew ;

Hellerstein, Marc K. ;

Lee, Hui-Young ;

Samuel, Varman T. ;

Shulman, Gerald I. ;

Wang, Yuhui ;

Duncan, Robin E. ;

Kang, Chulho ;

Sul, Hei Sook .

CELL METABOLISM, 2011, 13 (06) :739-748

[2]

Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro [J].

Anthonsen, MW ;

Rönnstrand, L ;

Wernstedt, C ;

Degerman, E ;

Holm, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (01) :215-221

[3]

Regulation of Visceral and Subcutaneous Adipocyte Lipolysis by Acute AICAR-induced AMPK Activation [J].

Anthony, Nicole M. ;

Gaidhu, Mandeep P. ;

Ceddia, Rolando B. .

OBESITY, 2009, 17 (07) :1312-1317

[4]

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD [J].

Baas, AF ;

Boudeau, J ;

Sapkota, GP ;

Smit, L ;

Medema, R ;

Morrice, NA ;

Alessi, DR ;

Clevers, HC .

EMBO JOURNAL, 2003, 22 (12) :3062-3072

[5]

Cold tolerance, cold-induced hyperphagia, and nonshivering thermogenesis are normal in α1-AMPK-/- mice [J].

Bauwens, Jake D. ;

Schmuck, Eric G. ;

Lindholm, Christopher R. ;

Ertel, Rebecca L. ;

Mulligan, Jacob D. ;

Hovis, Ian ;

Viollet, Benoit ;

Saupe, Kurt W. .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2011, 301 (02) :R473-R483

[6]

Bays Harold E, 2008, Expert Rev Cardiovasc Ther, V6, P343, DOI 10.1586/14779072.6.3.343

[7]

MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm [J].

Boudeau, J ;

Baas, AF ;

Deak, M ;

Morrice, NA ;

Kieloch, A ;

Schutkowski, M ;

Prescott, AR ;

Clevers, HC ;

Alessi, DR .

EMBO JOURNAL, 2003, 22 (19) :5102-5114

[8]

AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study [J].

Boyle, J. G. ;

Logan, P. J. ;

Jones, G. C. ;

Small, M. ;

Sattar, N. ;

Connell, J. M. C. ;

Cleland, S. J. ;

Salt, I. P. .

DIABETOLOGIA, 2011, 54 (07) :1799-1809

[9]

EFFECTS OF HORMONES ON THE RATE OF THE TRIACYLGLYCEROL FATTY-ACID SUBSTRATE CYCLE IN ADIPOCYTES AND EPIDIDYMAL FAT PADS [J].

BROOKS, B ;

ARCH, JRS ;

NEWSHOLME, EA .

FEBS LETTERS, 1982, 146 (02) :327-330

[10]

Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis [J].

Ceddia, RB .

INTERNATIONAL JOURNAL OF OBESITY, 2005, 29 (10) :1175-1183

← 1 2 3 4 5 6 7 8 9 10 →