Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil

被引：27

作者：

Ishida, T

Takanashi, Y

Kiwada, H

机构：

[1] Univ Tokushima, Grad Sch, Dept Pharmacokinet & Biopharmaceut, Inst Hlth Biosci, Tokushima 7708505, Japan

[2] Int Univ Hlth & Welf, Div Neurosurg, Atami Med Ctr, Shizuoka 4130012, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2006年 / 29卷 / 03期

关键词：

intrathecal delivery; liposome; cerebral ischemia; cerebral vasospasm; drug delivery system (DDS);

D O I：

10.1248/bpb.29.397

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmacological treatment for cerebral ischemia and cerebral vasospasm following subarachnoid hemorrhage (SAH) cannot attain sufficiently high concentrations of the drugs in the cerebrospinal fluid (CSF) without precipitating systemic side effects. We recently developed a liposomal drug delivery system for intrathecal application that can maintain effective concentrations of cerebral vasodilator, fasudil, in the CSF. A single intrathecal injection of liposomal fasudil could maintain a therapeutic drug concentration in the CSF over a period time due to their sustained-release property, significantly decreasing infarct size in a rat model of acute ischemia and reducing vasoconstriction of the rat and (log basilar artery in a model of SAH. In this review, we are introducing our new less-invasive intrathecal drug delivery system that provides an alternative and safe method to deliver therapeutic agents.

引用

页码：397 / 402

页数：6

共 52 条

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