Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania

被引：172

作者：

Frey, Benicio N.

Andreazza, Ana C.

Cereser, Keila M. M.

Martins, Marcio R.

Valvassori, Samira S.

Reus, Gislaine Z.

Quevedo, Joao

Kapczinski, Flavio

机构：

[1] Hosp Clin Porto Alegre, Biopolar Disorders Program, Ctr Pesquisas, BR-90035003 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Biochem, BR-90035003 Porto Alegre, RS, Brazil

[3] Univ Extremo Catarinese, Lab Neurociencias, BR-88806000 Criciuma, SC, Brazil

来源：

LIFE SCIENCES | 2006年 / 79卷 / 03期

关键词：

amphetamine; bipolar disorder; brain-derived neurotrophic factor; lithium; mania; valproate;

D O I：

10.1016/j.lfs.2006.01.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

There is an emerging body of data suggesting that mood disorders are associated with decreased brain-derived neurotrophic factor (BDNF). The present study aims to investigate the effects of the mood stabilizers lithium (Li) and valproate (VPT) in an animal model of bipolar disorder. In the first experiment (acute treatment), rats were administered D-amphetamine (AMPH) or saline for 14 days, and then between day 8 and 14, rats were treated with either Li, VPT or saline. In the second experiment (maintenance treatment), rats were pretreated with Li, VPT or saline, and then between day 8 and 14, rats were administered AMPH or saline. In both experiments, locomotor activity was measured using the open-field test and BDNF levels were measured in rat hippocampus by sandwich-ELISA. Li and VPT reversed AMPH-induced behavioral effects in the open-field test in both experiments. In the first experiment, Li increased BDNF levels in rat hippocampus. In the second experiment, AMPH decreased BDNF levels and Li and VPT increased BDNF levels in rat hippocampus. Our results suggest that the present model fulfills adequate face, construct and predictive validity as an animal model of mania. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：281 / 286

页数：6

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