Efficient synthesis of quinazolinones as intermediates of CNS agents via inverse-electron demand Diels-Alder reaction

被引：19

作者：

Bilbao, ER ^{[1
]}

Alvarado, M ^{[1
]}

Masaguer, CF ^{[1
]}

Raviña, E ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Farm, Quim Farmaceut Lab, Dept Quim Organ, E-15782 Santiago De Compostela, Spain

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 19期

关键词：

Diels Alder reactions; enamino ketones; quinazolinones triazines;

D O I：

10.1016/S0040-4039(02)00563-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enaminones Undergo inverse electron demand Diels-Alder reaction with 1,3,5-triazine, allowing access to functionalised quinazolinones as intermediates in the synthesis of CNS agents. This reaction is highly dependent of the solvent: 1,3,5-triazine undergoes single or double [4+2] cycloadditions with enaminones, and quinazolinones or acridinediones can be selectively obtained. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3551 / 3554

页数：4

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