Treatment of transplanted CT26 tumour with dendritic cell vaccine in combination with blockade of vascular endothelial growth factor receptor 2 and CTLA-4

被引：41

作者：

Pedersen, A. E. ^{[1
]}

Buus, S.

Claesson, M. H.

机构：

[1] Univ Copenhagen, Panum Inst, Dept Med Anat A, Cellular Immunol Lab, Copenhagen, Denmark

[2] Univ Copenhagen, Panum Inst, Inst Med Microbiol & Immunol, Copenhagen, Denmark

来源：

CANCER LETTERS | 2006年 / 235卷 / 02期

关键词：

dendritic cells; vaccine; colon carcinoma; angiogenesis; VEGF; CTLA-4;

D O I：

10.1016/j.canlet.2005.04.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the anti CT26 tumour effect of dendritic cell based vaccination with the MuLV gp70 envelope protein derived peptides AH1 and p320-333. Vaccination lead to generation of AH1 specific cytotoxic lymphocytes (CTL) and some decrease in tumour growth of simultaneously inoculated CT26 cells. After combination with an antibody against VEGF receptor 2 (DC101), a significant increase in survival of the tumour cell recipients was observed. Also, monotherapy with an antibody against CTLA-4 (9H10), led to approximately 100% survival of tumour cell recipients. However, effective treatment of mice with already established tumours was only obtained after combination of vaccination, DC101 and 9H10 treatment in which setting 80% of the mice rejected their tumours. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：229 / 238

页数：10

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