Epinephrine absorption in adults: Intramuscular versus subcutaneous injection

被引：316

作者：

Estelle, F

Simons, R

Gu, XC

Simons, KJ

机构：

[1] Univ Manitoba, Fac Med, Dept Pediat & Child Hlth, Allergy & Clin Immunol Sect, Winnipeg, MB, Canada

[2] Univ Manitoba, Fac Pharm, Div Pharmaceut Sci, Winnipeg, MB R3T 2N2, Canada

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2001年 / 108卷 / 05期

关键词：

epinephrine; adrenaline; EpiPen; systemic anaphylaxis; anaphylactic shock; acute allergic reaction; adult; intramuscular; subcutaneous;

D O I：

10.1067/mai.2001.119409

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We report a prospective, randomized, blinded, placebo-controlled, 6-way crossover study of intramuscular versus subcutaneous injection of epinephrine in young men. Peak plasma epinephrine concentrations were significantly higher (P < .01) after epinephrine was injected intramuscularly into the thigh than after epinephrine was injected intramuscularly or subcutaneously into the upper arm. We recommend intramuscular injection of epinephrine into the thigh as the preferred route and site of injection of this life-saving medication in the initial treatment of anaphylaxis.

引用

页码：871 / 873

页数：3

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