Changes and significance of IL-25 in chicken collagen II-induced experimental arthritis (CIA)

被引：25

作者：

Wang Kaiwen ^{[1
]}

Su Zhaoliang ^{[1
]}

Zhao Yinxia ^{[1
]}

Siamak, Sandoghchian Shotorbani ^{[1
]}

Jiao Zhijun ^{[2
]}

Xue Yuan ^{[1
]}

Yang Heng ^{[1
]}

Zheng Dong ^{[1
]}

Liu Yanfang ^{[1
]}

Shen Pei ^{[1
]}

Wang Shengjun ^{[1
]}

Shao Qixiang ^{[1
]}

Huang Xinxiang ^{[1
]}

Lu Liwei ^{[3
]}

Xu Huaxi ^{[1
]}

机构：

[1] Jiangsu Univ, Dept Immunol, Inst Lab Med, Zhenjiang 212013, Peoples R China

[2] Jiangsu Univ, Dept Lab Med, Cent Lab, Affiliated Hosp, Zhenjiang 212013, Peoples R China

[3] Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China

来源：

RHEUMATOLOGY INTERNATIONAL | 2012年 / 32卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Collagen II-induced experimental arthritis (CIA); IL-25; IL-17; IL-4; DBA/1; mice; AUTOIMMUNE ARTHRITIS; CELLS; INFLAMMATION; EXPRESSION;

D O I：

10.1007/s00296-011-1955-2

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. It is a systemic inflammatory disease, characterized by chronic, symmetrical, multi-articular synovial arthritis. IL-25 (IL-17E) is a member of the recently emerged cytokine family (IL-17s), which is expressed in Th2 cells and bone marrow-derived mast cells. Unlike the other members of this family, IL-25 is capable of inducing Th2-associated cytokines (IL-4, IL-5, and IL-13) and also promotes the release of some pro-immune factors (IL-6 and IL-8). IL-25 is also a pleiotropic factor, which constitutes a tissue-specific pathological injury and chronic inflammation. In this study, we used chicken collagen II-induced experimental arthritis (CIA) model in DBA/1 mice to investigate the relationship between IL-25 and other inflammatory factors, revealing the possible mechanism in CIA. Our results showed that the expression level of IL-25 was enhanced in the late stage of CIA, and IL-17 was increased in the early stage of the disease. It is well known that IL-17 has a crucial role in the development of RA pathogenesis, and IL-25 plays a significant role in humoral immune. For reasons given above, we suggested that the IL-25 inhibited IL-17 expression to some extent, while enhancing the production of IL-4. It was confirmed that IL-25 not only regulated the cellular immune, but also involved the humoral immune in rheumatoid arthritis.

引用

页码：2331 / 2338

页数：8

共 17 条

[1]

Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma [J].