Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China

被引：282

作者：

Tan, Mingkai ^{[1
]}

Liu, Yanxia ^{[1
]}

Zhou, Ruiping ^{[1
]}

Deng, Xilong ^{[1
]}

Li, Fang ^{[1
]}

Liang, Kaiyan ^{[1
]}

Shi, Yaling ^{[1
]}

机构：

[1] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Guangzhou 510000, Peoples R China

来源：

IMMUNOLOGY | 2020年 / 160卷 / 03期

关键词：

coronavirus disease 2019; cytokines; immune cells; inflammation; severe acute respiratory syndrome coronavirus 2; SARS-CORONAVIRUS; INTERFERON-GAMMA; COVID-19; RESPONSES;

D O I：

10.1111/imm.13223

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coronavirus disease 2019 (COVID-19) is a respiratory disorder caused by the highly contagious severe acute respiratory syndrome coronavirus 2. The immunopathological characteristics of patients with COVID-19, either systemic or local, have not been thoroughly studied. In the present study, we analysed both the changes in the number of various immune cell types as well as cytokines important for immune reactions and inflammation. Our data indicate that patients with severe COVID-19 exhibited an overall decline of lymphocytes including CD4(+)and CD8(+)T cells, B cells and natural killer cells. The number of immunosuppressive regulatory T cells was moderately increased in patients with mild COVID-19. Interleukin-6 (IL-6), IL-10 and C-reactive protein were remarkably up-regulated in patients with severe COVID-19. In conclusion, our study shows that the comprehensive decrease of lymphocytes, and the elevation of IL-6, IL-10 and C-reactive protein are reliable indicators of severe COVID-19.

引用

页码：261 / 268

页数：8

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