Estrogen differentially modulates nicotine-evoked dopamine release from the striatum of male and female rats

被引：58

作者：

Dluzen, DE

Anderson, LI

机构：

[1] Department of Anatomy, Northeastern Ohio Universities, College of Medicine, Rootstown, OH 44272-0095

来源：

NEUROSCIENCE LETTERS | 1997年 / 230卷 / 02期

关键词：

sex differences; gonadal steroids; nigrostriatal; dopamine release; dopamine transporter; smoking;

D O I：

10.1016/S0304-3940(97)00487-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present experiment we examined the effects of an in vitro infusion of nicotine (10 mu M) upon dopamine release from superfused striatum of castrated male and female rats treated or not treated with estrogen. Estrogen exerted bidirectional effects on nicotine-evoked dopamine release as a function of the sex of the animal. Nicotine-evoked dopamine release was increased in estrogen treated females and decreased in estrogen treated males. Peak nicotine-evoked dopamine output from estrogen treated females was significantly greater than that of estrogen treated males. These results may be related to the gender differences in response to nicotine and smoking behavior. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：140 / 142

页数：3

共 18 条

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