Intracellular and extracellular tau

被引：37

作者：

Avila, Jesus ^{[1
,2
]}

机构：

[1] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, Campus Cantoblanco,Nicolas Cabrera 3, Madrid 28050, Spain

[2] Univ Complutense, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain

来源：

FRONTIERS IN NEUROSCIENCE | 2010年 / 4卷

关键词：

tau; toxicity; Alzheimer disease; tauopathies;

D O I：

10.3389/fnins.2010.00049

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this short review is described the toxicity of modified intracellular tau and that of extracellular tau that could be released into the extracellular space after neuron death.

引用

页数：4

共 58 条

[1] Abnormal phosphorylation of tan and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau [J].

Alonso, AD ;

GrundkeIqbal, I ;

Barra, HS ;

Iqbal, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (01) :298-303

[2] Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies [J].

Alonso, Alejandra del C. ;

Li, Ben ;

Grundke-Iqbal, Inge ;

Iqbal, Khalid .

CURRENT ALZHEIMER RESEARCH, 2008, 5 (04) :375-384

[3] Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity [J].

Alonso, Alejandra Del C. ;

Li, Bin ;

Grundke-Iqbal, Inge ;

Iqbal, Khalid .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (23) :8864-8869

[4] Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms [J].

Andorfer, C ;

Acker, CM ;

Kress, Y ;

Hof, PR ;

Duff, K ;

Davies, P .

JOURNAL OF NEUROSCIENCE, 2005, 25 (22) :5446-5454

[5] Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals [J].

Arendt, T ;

Stieler, J ;

Strijkstra, AM ;

Hut, RA ;

Rüdiger, J ;

Van der Zee, EA ;

Harkany, T ;

Holzer, M ;

Härtig, W .

JOURNAL OF NEUROSCIENCE, 2003, 23 (18) :6972-6981

[6] Role of tau protein in both physiological and pathological conditions [J].

Avila, J ;

Lucas, JJ ;

Pérez, M ;

Hernández, F .

PHYSIOLOGICAL REVIEWS, 2004, 84 (02) :361-384

[7] NEUROFIBRILLARY DEGENERATION AND NEURONAL LOSS IN ALZHEIMERS-DISEASE [J].

BONDAREFF, W ;

MOUNTJOY, CQ ;

ROTH, M ;

HAUSER, DL .

NEUROBIOLOGY OF AGING, 1989, 10 (06) :709-715

[8] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[9]

Bretteville A, 2008, J ALZHEIMERS DIS, V14, P431

[10] INHIBITION OF NEURITE POLARITY BY TAU ANTISENSE OLIGONUCLEOTIDES IN PRIMARY CEREBELLAR NEURONS [J].

CACERES, A ;

KOSIK, KS .

NATURE, 1990, 343 (6257) :461-463

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