Total synthesis of octalactin A via ring-closing metathesis reaction

被引：41

作者：

Buszek, KR ^{[1
]}

Sato, N ^{[1
]}

Jeong, Y ^{[1
]}

机构：

[1] Kansas State Univ, Dept Chem, Manhattan, KS 66506 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(01)02078-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：181 / 184

页数：4

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