Effect of curing Helicobacter pylori infection on intragastric acidity during treatment with ranitidine in patients with duodenal ulcer

被引:63
作者
Labenz, J
Tillenburg, B
Peitz, U
Verdu, E
Stolte, M
Borsch, G
Blum, AL
机构
[1] UNIV VAUDOIS,DIV GASTROENTEROL,LAUSANNE,SWITZERLAND
[2] KLINIKUM BAYREUTH,INST PATHOL,BAYREUTH,GERMANY
关键词
Helicobacter pylori; intragastric acidity; omeprazole; ranitidine;
D O I
10.1136/gut.41.1.33
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background-In patients with duodenal ulcer cure of Helicobacter pylori. infection resulted in a pronounced decrease in intragastric pH during treatment with omeprazole. Aim-To test the hypothesis that treatment of H pylori adversely affects the pH response to ranitidine. Patients-Eighteen patients with duodenal ulcer who were infected with H pylori were studied. Methods-Twenty four hour pH recordings were performed during treatment with ranitidine (300 mg) at night before and four to six weeks after cure of H pylori infection. Presence of H pylori was assessed by a rapid urease test, culture, histology, and a C-13 urea breath test. Also, the fasting gastrin concentrations were measured before and after treatment for H pylori infection. Results-Cure of H pylori infection resulted in a considerable improvement in both antral and corpus gastritis and a decrease in fasting gastrin concentrations. As a result of the cure the night time intragastric pH during treatment with ranitidine decreased (median pH 6.8 v 5.4; p = 0.007), whereas the acidity during the daytime was not affected, Conclusions-In patients with duodenal ulcer the intragastric pH during treatment with ranitidine depends on H pylori. However, the loss of effectiveness in altering pH seems to be less pronounced than previously found with omeprazole.
引用
收藏
页码:33 / 36
页数:4
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