ADVANCED SQUAMOUS CELL CARCINOMA OF THE OROPHARYNX: EFFICACY OF POSITRON EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY FOR DETERMINING PRIMARY TUMOR RESPONSE DURING INDUCTION CHEMOTHERAPY

被引：16

作者：

Chepeha, Douglas B. ^{[1
]}

Sacco, Assuntina G. ^{[1
]}

Oxford, Lance E. ^{[2
]}

Karamchandani, Rahul ^{[1
]}

Miller, Tamara H. ^{[1
]}

Teknos, Theodoros N. ^{[1
]}

Bradford, Carol R. ^{[1
]}

Eisbruch, Avraham ^{[3
]}

Worden, Frank M. ^{[4
]}

Urba, Susan G. ^{[4
]}

Mukherji, Suresh K. ^{[5
]}

Bui, Chuong ^{[6
]}

Frey, Kirk A. ^{[5
]}

Wolf, Gregory T. ^{[1
]}

Lee, Julia S. ^{[7
]}

机构：

[1] Univ Michigan, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA

[2] Baylor Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Dallas, TX USA

[3] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Internal Med Hematol Oncol, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

[6] Penrith NSW, Nepean Hosp, Dept Nucl Med, Sydney, NSW, Australia

[7] Univ Michigan, Ctr Canc, Ann Arbor, MI 48109 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2009年 / 31卷 / 04期

关键词：

oropharyngeal neoplasms; emission-computed tomography; antineoplastic combined chemotherapy protocols; squamous cell carcinoma; fluorodeoxyglucose-18; ADVANCED LARYNGEAL-CANCER; BREAST-CANCER; ORGAN-PRESERVATION; PERFUSION; THERAPY; PET;

D O I：

10.1002/hed.21006

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

Background. To evaluate the efficacy of fluorine-18-fluorodeoxyglucose emission tomography (FDG-PET) and CT versus endoscopy with biopsy under general anesthesia for estimating tumor volume reduction among patients treated with induction chemotherapy for advanced squamous cell carcinoma (SCC) of the oropharynx. Methods. Twelve patients with oropharyngeal SCC nested in a phase 11, induction chemoradiation. organ preservation trial (University of Michigan Cancer Center 9921) underwent tumor volume reduction estimation as assessed by FDG-PET, CT, and endoscopy with biopsy. Results. In 9 of 12 patients, FDG-PET, CT, and endoscopy demonstrated agreement in estimation of tumor reduction. Two patients had discordant results, whereas I patient was inadequately evaluated with FDG-PET. The kappa value for PET versus endoscopy was 0.62, which is categorized as substantial agreement. The kappa value for CT versus endoscopy was 0.40, which is categorized as fair agreement. Conclusion. FDG-PET may be as efficacious as endoscopy with biopsy under general anesthesia for estimating tumor volume reduction with induction chemotherapy. (C) 2009 Wiley Periodicals, Inc. Head Neck 31: 452-460, 2009

引用

页码：452 / 460

页数：9

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