Long term complete remission of severe nephrotic syndrome secondary to diffuse global (IV-G) lupus nephritis following autologous, haematopoietic peripheral stem (CD34+) cell transplantation

被引：19

作者：

Marmont, AM ^{[1
]}

Gualandi, F

van Lint, MT

Guastoni, C

Bacigalupo, A

机构：

[1] S Martinos Hosp, Div Haematol, Genoa, Italy

[2] S Martinos Hosp, Stem Cell & Transplantat Ctr, Genoa, Italy

[3] Osped Civile, Div Nephrol, Legnano, Italy

来源：

LUPUS | 2006年 / 15卷 / 01期

基金：

美国国家卫生研究院;

关键词：

autologous stem cell transplantation; lupus nephritis; nephrotic syndrome;

D O I：

10.1191/0961203306lu2241cr

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Autologous haematopoietic stem cell transplantation has become an accepted powerful therapeutic procedure for patients with severe, intractable SLE. Here we describe a 26-year old patient with stage IV-G diffuse global proliferative lupus nephritis and refractory nephrotic syndrome who responded to autologous peripheral stem cell transplantation (ASCT) after two mobilization procedures. Five years later the patient is in complete clinical and immunologic remission. The indications for ASCT and its mechanism of action are briefly discussed.

引用

页码：44 / 46

页数：3

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