Methanol solvate of the 1:1 molecular complex of trimethoprim and sulfadimidine

被引：21

作者：

Bettinetti, G ^{[1
]}

Sardone, N ^{[1
]}

机构：

[1] UNIV PAVIA,CTR GRANDI STRUMENTI,I-27100 PAVIA,ITALY

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1997年 / 53卷

关键词：

D O I：

10.1107/S0108270196014783

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the title complex, C14H18N4O3.C12H14N4O2S.CH4O, the molecular association between trimethoprim {5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine; TMP} and sulfadimidine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide; SDMD] is maintained by two N-H ... N hydrogen bonds with no proton transfer from the sulfonamide imino N atom to the pyrimidine N atom of TMP. The methanol solvate molecule is linked to an O atom of the sulfonamido group through a strong O-H ... O interaction and does not seem to play an important role in the crystal-packing stabilization.

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页码：594 / 597

页数：4

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