Development of a novel vertical high shear kneader and its performance in wet kneading of pharmaceutical powders

被引:18
作者
Watano, S
Okamoto, T
Tsuhari, M
Koizumi, I
Osako, Y
机构
[1] Univ Osaka Prefecture, Osaka 5998531, Japan
[2] Fuji Paudal Co Ltd, Osaka 5360005, Japan
关键词
wet kneading; vertical high shear kneader; extrusion pressure; pressure transmission; physical strength;
D O I
10.1248/cpb.50.341
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A novel multi-functional vertical high shear kneader has been developed. Wet kneading of pharmaceutical powders was conducted under various blade components and operating conditions. Compression properties of wet kneaded mass was analyzed and dispersion of binder liquid (water) among the mass was investigated by assaying tracer aqueous pigment. Pellets were produced through a dome type extrusion granulator with continuous extrusion pressure measurement device and a fluidized bed drier, and then the physical properties were measured. Quantitative relationship between the pellet's physical properties and the binder dispersion condition as well as the compression properties could be obtained. It was found that the newly developed kneader was very effective to uniformly disperse binder as well as impart high shear stress to the wet mass without generating obvious adhesion onto the vessel wall. It was also pointed, out that the extrusion pressure could determine the physical strength of pellet. This method proposes a, new methodology for continuous monitoring of kneading condition as well as predicting pellet's physical properties.
引用
收藏
页码:341 / 345
页数:5
相关论文
共 12 条
[1]  
ARAKAWA M, 1971, AM CERAM SOC BULL, V50, P933
[2]  
FUNAKOSHI Y, 1975, ZAIRYO, V24, P85
[3]  
MICHAELS AS, 1954, CHEM ENG PROG, V50, P604
[4]  
NAKAYAMA M, 1997, PLANT PROCESS, V39, P69
[5]  
OKADA K, 1994, PHARM TECH JPN, V10, P31
[6]  
*SOC JAP PHARM, 2001, JAP PHARM, P101
[7]   Measurement of physical strength of pharmaceutical extruded pellets [J].
Watano, S ;
Shimoda, E ;
Osako, Y .
CHEMICAL & PHARMACEUTICAL BULLETIN, 2002, 50 (01) :26-30
[8]   A fuzzy control system of high shear granulation using image processing [J].
Watano, S ;
Numa, T ;
Miyanami, K ;
Osako, Y .
POWDER TECHNOLOGY, 2001, 115 (02) :124-130
[9]   Quantitative analysis of water dispersion conditions and pressure transmission characteristics of a wet kneaded mass [J].
Watano, S ;
Furukawa, J ;
Osako, Y ;
Yasutomo, T .
CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (01) :64-68
[10]   Drying of granules in agitation fluidized bed [J].
Watano, S ;
Yeh, N ;
Miyanami, K .
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 1998, 31 (06) :908-913